Scabies in the age of increasing drug resistance
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Public Library of Science
Abstract
Scabies is an infestation of the skin by the mite Sarcoptes scabiei. It manifests with pruritic erythematous papules and excoriations, in addition to the pathognomonic burrows. Multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. This paper will review the mechanisms of resistance proposed in the literature and some of the potential solutions to this problem. © 2017 Khalil et al.
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Keywords
Animals, Atp-binding cassette transporters, Humans, Insecticide resistance, Insecticides, Sarcoptes scabiei, Scabies, Skin, Sodium channels, 4 aminobutyric acid, Abc transporter, Benzyl benzoate, Crotamiton, Dexamethasone, Fluazuron, Glutathione transferase, Guanine, Ivermectin, Ligand gated chloride channel, Lindane, Malathion, Moxidectin, Permethrin, Pesticide, Sulfur, Topical agent, Voltage gated sodium channel, Insecticide, Sodium channel, Cd4+ t lymphocyte, Cd8+ t lymphocyte, Clinical outcome, Disease transmission, Human, Impetigo, Microscopy, Nonhuman, Review, Sequence analysis, Skin disease, Staphylococcus aureus, Staphylococcus hominis, Streptococcus pyogenes, Vaccination, Animal, Complication, Drug effects, Metabolism, Parasitology