A young child with HIV and unsteady gait: A case report

Yazbeck, Nadine H.; Youssef, Yolla; Hanna-Wakim, Rima H.

doi:https://doi.org/10.1016/j.idcr.2019.e00643

A young child with HIV and unsteady gait: A case report

Files

2020-3522.pdf (224 KB)

Date

2020

Authors

Yazbeck, Nadine H.

Youssef, Yolla

Hanna-Wakim, Rima H.

Publisher

Elsevier Ltd

Abstract

Background: We would like to raise awareness about the toxicities related to the added excipients present in the oral solution of Liponavir/ritonavir in particular alcohol and propylene glycol. Case presentation: In this case report, we describe an 18 month-old child with a newly diagnosed HIV infection on antiretroviral therapy (ART). She developed shortly after starting the ART unsteady gait and imbalance. Conclusions: The excipient-excipient interaction in Lopinavir/ritonavir may contribute to major toxicities not only in premature neonates and infants; but also in older children specifically from Asian ethnicity. © 2019 The Author(s)

Keywords

Hiv, Lopinavir-ritonavir, Unsteady gait, Alanine aminotransferase, Aspartate aminotransferase, Lamivudine, Lopinavir plus ritonavir, Zidovudine, Abnormally high substrate concentration in blood, Acute hiv infection, Antiretroviral therapy, Article, Body weight loss, Case report, Cd4 lymphocyte count, Child, Clinical article, Disease duration, Dosing error, Female, Fever, Human, Lymphadenopathy, Priority journal, Virus load