Development and Challenges of Synthetic Retinoid Formulations in Cancer
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Bentham Science Publishers
Abstract
Retinoids represent a class of chemical compounds derived from or structurally and functionally related to vitamin A. Retinoids play crucial roles in regulating a range of crucial biological processes spanning embryonic development to adult life. These include regulation of cell proliferation, differentiation, and cell death. Due to their promising characteristics, retinoids emerged as potent anti-cancer agents, and their effects were validated in vitro and in vivo preclinical models of several solid and hematological malignancies. However, their clinical translation remained limited due to poor water solubility, photosensitivity, short half-life, and toxicity. The development of retinoid delivery formulations was extensively studied to overcome these limitations. This review will summarize some preclinical and commercial synthetic retinoids in cancer and discuss their different delivery systems. © 2023 Bentham Science Publishers.
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Cancer, Delivery system, Development, Drug, Formulation, Synthetic retinoid, Antineoplastic agents, Cell differentiation, Humans, Neoplasms, Retinoids, Vitamin a, Adarotene, Albumin, Bexarotene, Copolymer, Doxorubicin, Fenretinide, Gel, Lenalidomide, Liposome, Microsphere, Nanoparticle, Paclitaxel, Phospholipid, Polyglactin, Retinoic acid, Retinoic acid binding protein, Retinoid, Retinoid x receptor, Retinoid x receptor alpha, Silicon dioxide, Soluplus, St1926 nanoparticle, Tamibarotene, Trifarotene, Unclassified drug, Antineoplastic agent, Retinol, Acne vulgaris, Antineoplastic activity, Aqueous solution, Cell death, Cell proliferation, Commercial phenomena, Drug delivery system, Drug formulation, Drug half life, Human, Hypertriglyceridemia, Hypothyroidism, In vitro study, In vivo study, Malignant neoplasm, Micelle, Nanoencapsulation, Photosensitivity, Preclinical study, Review, T cell lymphoma, Water solubility, Metabolism, Neoplasm