Hematological malignancies in connective tissue diseases
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SAGE Publications Ltd
Abstract
Chronic inflammation has profound tumor-promoting effects. Inflammatory cells are the key players in immunosurveillance against tumors, and immunosuppression is known to increase the risk of tumors. Autoimmune diseases, which manifest as loss of self-tolerance and chronic immune dysregulation, provide a perfect environment for tumor development. Aside from managing the direct inflammatory consequences of autoimmune pathogenesis, cancer risk profiles should be considered as a part of a patient's treatment. In this review, we describe the various associations of malignancies with autoimmune diseases, specifically systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and Sjögren's syndrome, as well as discuss the mechanisms contributing to the pathogenesis of both disorders. © The Author(s) 2020.
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Hematological malignancies, Inflammation, Rheumatoid arthritis, Sjögren's syndrome, Systemic lupus erythematosus, Systemic sclerosis, Autoimmune diseases, Connective tissue diseases, Hematologic neoplasms, Humans, Lupus erythematosus, systemic, Rheumatic diseases, Risk factors, Scleroderma, systemic, Sjogren's syndrome, Cyclophosphamide, Disease modifying antirheumatic drug, Tumor necrosis factor inhibitor, Autoimmune disease, Bladder cancer, Chronic inflammation, Connective tissue disease, Disease association, Epigenetics, Genetics, Hematologic malignancy, Human, Nonhuman, Pathogenesis, Pathophysiology, Priority journal, Review, Risk factor, Sjoegren syndrome, Complication, Hematologic disease, Rheumatic disease