Comparison of the performance of the Cepheid Xpert HemosIL Factor II and Factor V and the ViennaLab FV-PTH-MTHFR StripAssay kits for molecular thrombophilia profiling
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Abstract
Aims: To compare the performance of two assays used for the detection of mutations/polymorphisms in the Factor V, Factor II, and methylenetetrahydrofolate reductase genes among patients referred for the management of a thrombotic event. Materials and Methods: We tested 40 different patient samples using two assays, the ViennaLab FV-PTH-MTHFR StripAssay and the Cepheid Xpert HemosIL. Results: The two assays were 100% concordant in their produced results with no samples failing the testing procedures in both. Conclusion: This is the first report to evaluate the performance of the ViennaLab FV-PTH-MTHFR StripAssay and the Cepheid Xpert HemosIL. Both assays can be introduced to the operation of molecular diagnostic laboratories to cover the referrals from different disciplines, especially in tertiary care centers with emergency departments. © Mary Ann Liebert, Inc.
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Dna mutational analysis, Factor v, Gene expression profiling, Genotyping techniques, Humans, Methylenetetrahydrofolate reductase (nadph2), Molecular diagnostic techniques, Polymorphism, genetic, Prothrombin, Reagent kits, diagnostic, Reagent strips, Thrombophilia, Blood clotting factor 5, Diagnostic kit, Mthfr protein, human, Test strip, Article, Cepheid xpert hemosil factor ii and factor v assay, Clinical article, Controlled study, Gene mutation, Genetic screening, Genotyping technique, Human, Molecular diagnosis, Single nucleotide polymorphism, Tertiary care center, Viennalab fv pth mthfr stripassay kit, Comparative study, Evaluation study, Genetic polymorphism, Genetics, Nucleotide sequence, Procedures