Comparison of the performance of the Cepheid Xpert HemosIL Factor II and Factor V and the ViennaLab FV-PTH-MTHFR StripAssay kits for molecular thrombophilia profiling

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dc.contributor.authorHoteit, Rouba M.
dc.contributor.authorHassanieh, Sylvana
dc.contributor.authorMahfouz, Rami A.R.
dc.contributor.departmentPathology and Laboratory Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:09:49Z
dc.date.available2025-01-24T12:09:49Z
dc.date.issued2014
dc.description.abstractAims: To compare the performance of two assays used for the detection of mutations/polymorphisms in the Factor V, Factor II, and methylenetetrahydrofolate reductase genes among patients referred for the management of a thrombotic event. Materials and Methods: We tested 40 different patient samples using two assays, the ViennaLab FV-PTH-MTHFR StripAssay and the Cepheid Xpert HemosIL. Results: The two assays were 100% concordant in their produced results with no samples failing the testing procedures in both. Conclusion: This is the first report to evaluate the performance of the ViennaLab FV-PTH-MTHFR StripAssay and the Cepheid Xpert HemosIL. Both assays can be introduced to the operation of molecular diagnostic laboratories to cover the referrals from different disciplines, especially in tertiary care centers with emergency departments. © Mary Ann Liebert, Inc.
dc.identifier.doihttps://doi.org/10.1089/gtmb.2013.0379
dc.identifier.eid2-s2.0-84896759346
dc.identifier.pmid24401045
dc.identifier.urihttp://hdl.handle.net/10938/32135
dc.language.isoen
dc.relation.ispartofGenetic Testing and Molecular Biomarkers
dc.sourceScopus
dc.subjectDna mutational analysis
dc.subjectFactor v
dc.subjectGene expression profiling
dc.subjectGenotyping techniques
dc.subjectHumans
dc.subjectMethylenetetrahydrofolate reductase (nadph2)
dc.subjectMolecular diagnostic techniques
dc.subjectPolymorphism, genetic
dc.subjectProthrombin
dc.subjectReagent kits, diagnostic
dc.subjectReagent strips
dc.subjectThrombophilia
dc.subjectBlood clotting factor 5
dc.subjectDiagnostic kit
dc.subjectMthfr protein, human
dc.subjectTest strip
dc.subjectArticle
dc.subjectCepheid xpert hemosil factor ii and factor v assay
dc.subjectClinical article
dc.subjectControlled study
dc.subjectGene mutation
dc.subjectGenetic screening
dc.subjectGenotyping technique
dc.subjectHuman
dc.subjectMolecular diagnosis
dc.subjectSingle nucleotide polymorphism
dc.subjectTertiary care center
dc.subjectViennalab fv pth mthfr stripassay kit
dc.subjectComparative study
dc.subjectEvaluation study
dc.subjectGenetic polymorphism
dc.subjectGenetics
dc.subjectNucleotide sequence
dc.subjectProcedures
dc.titleComparison of the performance of the Cepheid Xpert HemosIL Factor II and Factor V and the ViennaLab FV-PTH-MTHFR StripAssay kits for molecular thrombophilia profiling
dc.typeArticle

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