Tocilizumab in the Treatment of Eosinophilic Fasciitis: A Case Study and Review of Literature
Loading...
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Greek Rheumatology Society and Professional Association of Rheumatologists
Abstract
Eosinophilic fasciitis (EF) is a rare connective-tissue disorder that is characterised by subacute onset of erythema, oedema, and induration of the skin and soft tissues of the limbs and trunk. Although several triggers have been hypothesised to be associated with EF, the aetiology of eosinophilic fasciitis (EF) is still unclear, and several treatment regimens have been proposed to treat this disease. In this article, we report a case of a 72-year-old gentleman with multiple comorbidities who presented to the clinic for diffuse skin thickening present on his forearms, thighs, legs bilaterally, and over the pelvis. The patient was diagnosed with EF and failed multiple treatment regimens including prednisone, methotrexate, rituximab, but finally responded and was maintained on tocilizumab. In this article, we will review the current understanding of EF, diagnostic approach, popular treatments and review other cases of EF in which tocilizumab was used © This work is licensed under a Creative Commons Attribution 4.0 International License
Description
Keywords
Eosinophilic fasciitis, Shulman’s disease, Tocilizumab, Azathioprine, C reactive protein, Cyclophosphamide, Cyclosporine, Deflazacort, Ebastine, Etanercept, Folic acid, Immunoglobulin, Methotrexate, Mycophenolic acid, Prednisone, Reslizumab, Risedronic acid, Rituximab, Vitamin d, Aged, Blood cell count, Body weight loss, Case report, Chronic obstructive lung disease, Cigarette smoking, Clinical article, Comorbidity, Computer assisted tomography, Differential diagnosis, Drug dose increase, Drug substitution, Drug withdrawal, Elasticity, Eosinophil count, Eosinophilia myalgia syndrome, Erythema, Erythrocyte sedimentation rate, Forearm, Human, Hypertension, Laboratory test, Leg, Leukocyte count, Linear scleroderma, Male, Morphea, Non insulin dependent diabetes mellitus, Paraneoplastic syndrome, Pelvis, Peripheral t cell lymphoma, Physical examination, Review, Scleroderma, Skin biopsy, Skin edema, Skin fibrosis, Skin induration, Skin thickness, Systemic sclerosis, Thigh, Toxic oil syndrome, Treatment outcome, Treatment response