Effect of vitamin D replacement on immunological biomarkers in patients with multiple sclerosis
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Academic Press Inc.
Abstract
We aimed to investigate the immunologic effects of vitamin D replacement in RRMS patients. In a controlled single center study, patients deficient in 25-hydroxyvitamin D (serum level < 25 ng/ml) received 10,000 IU/week cholecalciferol for 3 months. Sufficient vitamin D patients (serum level > 35 ng/ml) were followed for the same period. Assessments were performed at baseline and at 3 months. 25-hydroxyvitamin D levels increased significantly from baseline to month-3 in the deficient group after treatment and remained stable in the sufficient group. We observed a decreased interferon-γ (IFNγ) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNγ production. There was no change in the frequency of T helper or regulatory T cell subsets in either group. Increasing serum levels of 25-hydroxyvitamin D are associated with decreased production of IFNγ by CD4+ T cells. © 2017 Elsevier Inc.
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Keywords
Cytometric bead array, Immunophenotyping, Interferon gamma, Relapsing remitting multiple sclerosis, T cells, Vitamin d, Adult, Cd4-positive t-lymphocytes, Cholecalciferol, Controlled before-after studies, Cytokines, Female, Humans, Interferon-gamma, Male, Middle aged, Multiple sclerosis, relapsing-remitting, Treatment outcome, Vitamin d deficiency, Vitamins, Young adult, 25 hydroxyvitamin d, Beta1a interferon, Cd161 antigen, Cd3 antibody, Cd3 antigen, Cd4 antibody, Cd4 antigen, Chemokine receptor ccr6, Gamma interferon, Granulocyte macrophage colony stimulating factor, Interferon beta serine, Interleukin 10, Interleukin 17, Interleukin 2, Interleukin 23 receptor, Interleukin 4, Interleukin 6, Tumor necrosis factor, 25-hydroxyvitamin d, Colecalciferol, Cytokine, Vitamin, Article, Cd4+ t lymphocyte, Clinical article, Clinical assessment, Controlled study, Drug effect, Drug megadose, Helper cell, Human, In vivo study, Multiple sclerosis, Priority journal, Regulatory t lymphocyte, Therapy effect, Treatment duration, Vitamin blood level, Vitamin supplementation, Analogs and derivatives, Blood, Complication, Epidemiology, Immunology