Genetic markers of chronic lymphocytic leukemia: a retrospective study of 312 patients from a reference center in Lebanon
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Newlands Press Ltd
Abstract
Aim: Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values - mainly immunoglobulin heavy chain variable region gene (IGHV) mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. Patients & methods: In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Results: Prominent IGHV genes were IGHV4-34, IGHV1-69 and IGHV3-30; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. Conclusion: The distribution of IGHV alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis. © 2023 Future Medicine Ltd.
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Biomarkers, Chronic lymphocytic leukemia, Cll, Cytogenetics, Fish, Ighv, Karyotype, Lebanon, Molecular diagnosis, Genes, immunoglobulin heavy chain, Genetic markers, Humans, Immunoglobulin variable region, Leukemia, lymphocytic, chronic, b-cell, Mutation, Prognosis, Retrospective studies, Adult, Aged, Allele, Antigen detection, Article, Blood sampling, Cancer prognosis, Chronic lymphatic leukemia, Controlled study, Demography, Female, Fluorescence in situ hybridization, Gene, Gene identification, Gene rearrangement, Genetic analysis, Genetic association, Genetic marker, Heredity, Human, Ighv gene, Ighv1 69 gene, Ighv3 30 gene, Ighv4 34 gene, Major clinical study, Male, Mutational analysis, Personalized medicine, Retrospective study, Genetics, Immunoglobulin heavy chain gene