Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex

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dc.contributor.authorMroueh, Mohamad A.
dc.contributor.authorDaher, Costantine F.
dc.contributor.authorHariri, Essa H.
dc.contributor.authorDemirdjian, Sally
dc.contributor.authorIsber, Samih
dc.contributor.authorChoi, Eunsang
dc.contributor.authorMirtamizdoust, Babak
dc.contributor.authorHammud, Hassan Hasan
dc.contributor.departmentDepartment of Physics
dc.contributor.facultyFaculty of Arts and Sciences (FAS)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:25:04Z
dc.date.available2025-01-24T11:25:04Z
dc.date.issued2015
dc.description.abstractThe dinuclear complex bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property. © 2015, Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doihttps://doi.org/10.1016/j.cbi.2015.02.023
dc.identifier.eid2-s2.0-84924388873
dc.identifier.pmid25753321
dc.identifier.urihttp://hdl.handle.net/10938/26186
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofChemico-Biological Interactions
dc.sourceScopus
dc.subjectAnticancer
dc.subjectCopper(ii) phenanthroline
dc.subjectDft
dc.subjectIn vitro cytotoxicity
dc.subjectMagnetism
dc.subjectThermal
dc.subjectAntineoplastic agents
dc.subjectCell line, tumor
dc.subjectCoordination complexes
dc.subjectCopper
dc.subjectCrystallography, x-ray
dc.subjectHalogenation
dc.subjectHumans
dc.subjectMagnetic phenomena
dc.subjectModels, molecular
dc.subjectNeoplasms
dc.subjectPhenanthrolines
dc.subjectAntineoplastic agent
dc.subjectBis[(mu2 chloro)chloro(1,10 phenanthroline)copper]complex
dc.subjectCisplatin
dc.subjectUnclassified drug
dc.subject1,10-phenanthroline
dc.subjectCoordination compound
dc.subjectPhenanthroline derivative
dc.subjectAdult
dc.subjectAntineoplastic activity
dc.subjectAntiproliferative activity
dc.subjectArticle
dc.subjectAstrocytoma cell line
dc.subjectBreast adenocarcinoma
dc.subjectCancer chemotherapy
dc.subjectColon adenocarcinoma
dc.subjectControlled study
dc.subjectDensity functional theory
dc.subjectDrug cytotoxicity
dc.subjectDrug efficacy
dc.subjectDrug potency
dc.subjectDrug safety
dc.subjectDrug screening
dc.subjectDrug structure
dc.subjectDrug synthesis
dc.subjectHuman
dc.subjectHuman cell
dc.subjectIc50
dc.subjectIn vitro study
dc.subjectIn vivo study
dc.subjectInfrared spectroscopy
dc.subjectLd 50
dc.subjectLung adenocarcinoma
dc.subjectMale
dc.subjectMelanoma b16
dc.subjectNonhuman
dc.subjectRat
dc.subjectThermal analysis
dc.subjectX ray analysis
dc.subjectChemical structure
dc.subjectChemistry
dc.subjectTumor cell line
dc.subjectX ray crystallography
dc.titleMagnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex
dc.typeArticle

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