Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors
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Springer
Abstract
The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression. © 2019, The Author(s).
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Atrial natriuretic peptide, anp, Autonomic nervous system, B-type natriuretic peptide, bnp, C-type natriuretic peptide, cnp, Natriuretic peptide receptor a, npra, Natriuretic peptide receptor b, nprb, Natriuretic peptide receptor c, nprc, Oral squamous cell carcinoma, Salivary gland, Submandibular gland, Animals, Atrial natriuretic factor, Carcinoma, squamous cell, Female, Humans, Male, Mice, Mouth neoplasms, Natriuretic peptide, brain, Natriuretic peptide, c-type, Neoplasm proteins, Receptors, peptide, Brain natriuretic peptide, Electrolyte, Natriuretic peptide receptor a, Natriuretic peptide receptor b, Natriuretic peptide receptor c, Natriuretic peptide type c, Receptor, Tumor protein, Absorption, Animal tissue, Article, Autocrine effect, Autonomic nerve, Blood vessel wall, Cancer patient, Controlled study, Gene overexpression, Homeostasis, Human, Human tissue, Infant, Microvasculature, Mouse, Mouth squamous cell carcinoma, Nonhuman, Priority journal, Protein expression, Protein localization, Salivary gland function, Tumor invasion, Animal, Biosynthesis, Blood, Metabolism, Mouth tumor, Pathology, Squamous cell carcinoma, Vascularization