Routine surveillance imaging after end of therapy for pediatric extracranial tumors: A retrospective analysis
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John Wiley and Sons Inc.
Abstract
Frequent surveillance imaging is routine practice for pediatric patients after cancer therapy. This retrospective study evaluated the follow-up of 301 children with extracranial tumors diagnosed between 2002 and 2012, at a tertiary pediatric cancer center in Beirut, Lebanon. Recurrence occurred in 15% of patients, at a median of 12 months after end of primary therapy. Outcome was not different comparing patients with recurrence detected via imaging surveillance versus clinically. False positive findings in 55 patients led to further interventions. These results raise important questions regarding benefit of current surveillance practices as standard care, especially in countries with limited resources. © 2017 Wiley Periodicals, Inc.
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Keywords
Imaging, Pediatric oncology, Recurrence, Surveillance, Adolescent, Child, Child, preschool, Female, Follow-up studies, Head and neck neoplasms, Humans, Infant, Lebanon, Male, Retrospective studies, Tertiary care centers, Gallium, Article, Bone scintiscanning, Bone tumor, Cancer center, Cancer recurrence, Cancer survival, Cancer therapy, Childhood cancer, Clinical feature, Computer assisted tomography, Diagnostic imaging, Disease surveillance, False positive result, Follow up, Hodgkin disease, Human, Human tissue, Kaplan meier method, Lymphoma, Major clinical study, Nephroblastoma, Neuroblastoma, Nonhodgkin lymphoma, Nuclear magnetic resonance imaging, Osteosarcoma, Overall survival, Positron emission tomography, Priority journal, Recurrence risk, Retrospective study, Rhabdomyosarcoma, Solid malignant neoplasm, Synovial sarcoma, Treatment outcome, Tumor biopsy, Tumor regression, Clinical trial, Head and neck tumor, Preschool child, Tertiary care center