ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
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Elsevier Inc.
Abstract
Adenine nucleotide translocase 2 (ANT2) transports glycolytic ATP across the inner mitochondrial membrane. Patients with ANT2 deletion were recently reported. We aimed at characterizing mitochondrial functions in ANT2-defective fibroblasts. In spite of ANT2 expression in fibroblasts, we observed no difference between ANT2-defective and control fibroblasts for mitochondrial respiration, respiratory chain activities, mitochondrial membrane potential and intracellular ATP levels. This indicates that ANT2 insufficiency does not alter fibroblast basal mitochondrial bioenergetics. © 2015 Published by Elsevier Inc.
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Keywords
Adenine nucleotide translocase 2, Ant2, Mitochondria, Slc25a5, Adenine nucleotide translocase, Oligomycin, Unclassified drug, Article, Bioenergy, Cell growth, Controlled study, Fibroblast, Human, Human cell, Male, Mitochondrial membrane, Mitochondrial membrane potential, Mitochondrial respiration, Mitochondrion, Myoclonus epilepsy, Respiratory chain, Reverse transcription polymerase chain reaction