ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics

Simple item page
dc.contributor.authorPrabhu, Dolly
dc.contributor.authorGoldstein, Amy C.
dc.contributor.authorEl-Khoury, Riyad
dc.contributor.authorRak, Malgorzata
dc.contributor.authorEdmunds, Lia R.
dc.contributor.authorRustin, Pierre
dc.contributor.authorVockley, Jerry G.
dc.contributor.authorSchiff, Manuel
dc.contributor.departmentPathology and Laboratory Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:09:52Z
dc.date.available2025-01-24T12:09:52Z
dc.date.issued2015
dc.description.abstractAdenine nucleotide translocase 2 (ANT2) transports glycolytic ATP across the inner mitochondrial membrane. Patients with ANT2 deletion were recently reported. We aimed at characterizing mitochondrial functions in ANT2-defective fibroblasts. In spite of ANT2 expression in fibroblasts, we observed no difference between ANT2-defective and control fibroblasts for mitochondrial respiration, respiratory chain activities, mitochondrial membrane potential and intracellular ATP levels. This indicates that ANT2 insufficiency does not alter fibroblast basal mitochondrial bioenergetics. © 2015 Published by Elsevier Inc.
dc.identifier.doihttps://doi.org/10.1016/j.ymgmr.2015.03.005
dc.identifier.eid2-s2.0-84926178796
dc.identifier.urihttp://hdl.handle.net/10938/32166
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofMolecular Genetics and Metabolism Reports
dc.sourceScopus
dc.subjectAdenine nucleotide translocase 2
dc.subjectAnt2
dc.subjectMitochondria
dc.subjectSlc25a5
dc.subjectAdenine nucleotide translocase
dc.subjectOligomycin
dc.subjectUnclassified drug
dc.subjectArticle
dc.subjectBioenergy
dc.subjectCell growth
dc.subjectControlled study
dc.subjectFibroblast
dc.subjectHuman
dc.subjectHuman cell
dc.subjectMale
dc.subjectMitochondrial membrane
dc.subjectMitochondrial membrane potential
dc.subjectMitochondrial respiration
dc.subjectMitochondrion
dc.subjectMyoclonus epilepsy
dc.subjectRespiratory chain
dc.subjectReverse transcription polymerase chain reaction
dc.titleANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2015-5084.pdf
Size:
420.58 KB
Format:
Adobe Portable Document Format
Download

Collections

Pathology and Laboratory Medicine