B-cell acute lymphoblastic leukemia/lymphoma in relapse presenting as a cervical mass: A case report and review of literature
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Elsevier B.V.
Abstract
The involvement of the cervix as a site of relapse for hematologic malignancies is rare. We herein present a case of relapsed B-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL) mimicking advanced cervical cancer. The patient is a 61-year-old female with history B-cell ALL and had multiple relapses confined to the bone marrow and had received several different chemotherapy regimens. She presented with lower abdominal pain after the end of her last cycle for which an MRI abdomen and pelvis was done and it showed the presence of an asymmetrical cervical mass. Further imaging included a PET-CT showing the presence of hypermetabolic cervical mass with left pelvic and retroperitoneal lymph node involvement. She underwent a biopsy of 3 distinct lesions in the cervix and vagina and a diagnosis of relapsed B-cell ALL was confirmed in two out of the three specimens. © 2019 The Authors
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Cervical cancer, Diagnosis - relapse, Hematologic malignancy, Blinatumomab, Cyclophosphamide, Dexamethasone, Doxorubicin, Inotuzumab ozogamicin, Methotrexate, Ofatumumab, Prednisone, Rituximab, Venetoclax, Vincristine, Abdominal radiography, Acute lymphoblastic leukemia, Adult, Article, B lymphocyte, Backache, Bone marrow, Bone marrow biopsy, Cancer chemotherapy, Case report, Clinical article, Disease surveillance, Fatigue, Female, Human, Human tissue, Leukemia relapse, Lower abdominal pain, Lymphadenopathy, Middle aged, Nausea, Nuclear magnetic resonance imaging, Paraaortic lymph node, Pelvis radiography, Priority journal, Retroperitoneal disease, Supernumerary chromosome, Uterine cervix biopsy, Vagina