Epigenetic regulation of p21cip1/waf1 in human cancer

Simple item page
dc.contributor.authorOcker, Matthias
dc.contributor.authorBitar, Sara Al
dc.contributor.authorMonteiro, Ana Carolina M.
dc.contributor.authorGali-Muhtasib, Hala Uthman
dc.contributor.authorSchneider-Stock, Regine
dc.contributor.departmentDepartment of Biology
dc.contributor.facultyFaculty of Arts and Sciences (FAS)
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:20:49Z
dc.date.available2025-01-24T11:20:49Z
dc.date.issued2019
dc.description.abstractp21cip1/waf1 is a central regulator of cell cycle control and survival. While mutations are rare, it is commonly dysregulated in several human cancers due to epigenetic mechanisms influencing its transcriptional control. These mechanisms include promoter hypermethylation as well as additional pathways such as histone acetylation or methylation. The epigenetic regulators include writers, such as DNA methyltransferases (DNMTs); histone acetyltransferases (HATs) and histone lysine methyltransferases; erasers, such as histone deacetylases (HDACs); histone lysine demethylases [e.g., the Lysine Demethylase (KDM) family]; DNA hydroxylases; readers, such as the methyl-CpG-binding proteins (MBPs); and bromodomain-containing proteins, including the bromo-and extraterminal domain (BET) family. We further discuss the roles that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play in the epigenetic control of p21cip1/waf1 expression and its function in human cancers. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.identifier.doihttps://doi.org/10.3390/cancers11091343
dc.identifier.eid2-s2.0-85073272499
dc.identifier.urihttp://hdl.handle.net/10938/25143
dc.language.isoen
dc.publisherMDPI AG
dc.relation.ispartofCancers
dc.sourceScopus
dc.subjectDna methylation
dc.subjectEpigenetic eraser
dc.subjectEpigenetic reader
dc.subjectEpigenetic writer
dc.subjectHistone acetylation
dc.subjectHistone methylation
dc.subjectLncrna
dc.subjectMirna
dc.subjectP21cip1/waf1
dc.subjectCyclin dependent kinase inhibitor 1
dc.subjectCyclin dependent kinase inhibitor 1a
dc.subjectLong untranslated rna
dc.subjectMicrorna
dc.subjectMicrorna 1180
dc.subjectMicrorna 1236
dc.subjectMicrorna 17 5p
dc.subjectMicrorna 200c
dc.subjectMicrorna 208a
dc.subjectMicrorna 224
dc.subjectMicrorna 3619 5p
dc.subjectMicrorna 370
dc.subjectMicrorna 503 3p
dc.subjectMicrorna 6734
dc.subjectMicrorna 92a
dc.subjectMicrorna 93 5p
dc.subjectMicrorna 95 3p
dc.subjectUnclassified drug
dc.subjectAnril gene
dc.subjectBancr gene
dc.subjectBladder cancer
dc.subjectCancer cell
dc.subjectCarcinogenesis
dc.subjectCdkn1a gene
dc.subjectColon cancer
dc.subjectColorectal cancer
dc.subjectEpigenetics
dc.subjectEsophageal squamous cell carcinoma
dc.subjectGas5 gene
dc.subjectGene expression
dc.subjectGene function
dc.subjectGene overexpression
dc.subjectGenetic regulation
dc.subjectHead and neck squamous cell carcinoma
dc.subjectHotair gene
dc.subjectHoxa as2 gene
dc.subjectHuman
dc.subjectLiver cell carcinoma
dc.subjectMalignant neoplasm
dc.subjectMir31hg gene
dc.subjectNon small cell lung cancer
dc.subjectNonhuman
dc.subjectOncogene
dc.subjectOncogene myc
dc.subjectOsteosarcoma
dc.subjectP21 cip1 waf1 gene
dc.subjectPancreas adenocarcinoma
dc.subjectPromoter region
dc.subjectPvt1 gene
dc.subjectReview
dc.subjectStomach cancer
dc.subjectUterine cervix cancer
dc.titleEpigenetic regulation of p21cip1/waf1 in human cancer
dc.typeReview

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2019-7375.pdf
Size:
2.23 MB
Format:
Adobe Portable Document Format
Download

Collections

Department of Biology