Gram-Negative Skin and Soft Tissue Infections
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W.B. Saunders
Abstract
Skin and soft tissue infections (SSTIs) frequently are encountered in clinical practice, and gram-negative bacilli (GNB) constitute an underrated portion of their etiology. The rate of GNB-causing SSTIs is increasing, especially with the rise in antimicrobial resistance. Although the diagnosis of SSTIs mostly is clinical, rapid diagnostic modalities can shorten the time to initiating proper therapy and improving outcomes. Novel antibiotics are active against GNB SSTIs and can be of great value in the management. This review provides an overview of the role of GNB in SSTIs and summarizes their epidemiology, risk factors, outcome, and clinical management. © 2020 Elsevier Inc.
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Diagnosis, Epidemiology, Gram-negative, Skin and soft tissue infections, Treatment, Anti-bacterial agents, Drug resistance, multiple, bacterial, Gram-negative bacteria, Gram-negative bacterial infections, Humans, Incidence, Prognosis, Risk factors, Skin diseases, bacterial, Soft tissue infections, Amikacin, Aminoglycoside antibiotic agent, Amoxicillin plus clavulanic acid, Antibiotic agent, Avibactam plus aztreonam, Avibactam plus ceftaroline, Avibactam plus ceftazidime, Aztreonam, Carbapenem derivative, Cefepime, Cefiderocol, Cefotaxime, Ceftazidime, Ceftolozane plus tazobactam, Ceftriaxone, Cefuroxime, Cephalosporin derivative, Cilastatin plus imipenem, Cilastatin sodium plus imipenem plus relebactam, Ciprofloxacin, Colistin, Cotrimoxazole, Delafloxacin, Doripenem, Doxycycline, Eravacycline, Ertapenem, Finafloxacin, Fluorodeoxyglucose f 18, Fosfomycin, Gentamicin, Levofloxacin, Meropenem, Meropenem plus vaborbactam, Metronidazole, Minocycline, Murepavadin, Omadacycline, Piperacillin plus tazobactam, Plazomicin, Polymyxin b, Polymyxin derivative, Quinoline derived antiinfective agent, Sultamicillin, Tigecycline, Tobramycin, Unclassified drug, Antiinfective agent, Acinetobacter baumannii, Antibiotic resistance, Antibiotic therapy, Antimicrobial stewardship, Bacterial skin disease, Carbapenem resistant acinetobacter baumannii, Combination drug therapy, Diabetic foot, Diabetic foot infection, Drug megadose, Enterobacteriaceae, Escherichia coli, Extensive drug resistance, Gram negative infection, Human, Inappropriate prescribing, Klebsiella pneumoniae infection, Loading drug dose, Mediastinitis, Mixed infection, Monotherapy, Mortality rate, Multidrug resistance, Necrotizing fasciitis, Nonhuman, Pseudomonas aeruginosa, Pseudomonas infection, Review, Soft tissue infection, Gram negative bacterium, Isolation and purification, Risk factor