Intracerebroventricular injections of endotoxin (ET) reduces hippocampal neurogenesis
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Elsevier B.V.
Abstract
Physio-pathological conditions such as neuroinflammation can modulate neurogenesis in the hippocampus. The aim of this study is to follow the time course of inflammation-induced effects on the neurogenic niche and the counter-effects of an anti-inflammatory drug. Rats received intracerebroventricular injections of lipopolysaccharide/endotoxin (ET) and intraperitoneal injections of 5′-bromo-2′-deoxyuridine, then perfused at different time intervals. At day 3, ET injection resulted in thermal hyperalgesia accompanied by a significant decrease in neurogenesis. A rebound of neurogenesis was detected at day 6 and levels were back to basal at day 9. Daily treatment with Piroxicam alleviated the ET-induced effects. © 2017 Elsevier B.V.
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Dentate gyrus, Endotoxin, Neurodegeneration, Neurogenesis, Neuroinflammation, Nsaid, Animals, Anti-inflammatory agents, non-steroidal, Endotoxins, Hippocampus, Hyperalgesia, Inflammation, Injections, intraventricular, Male, Piroxicam, Rats, Rats, sprague-dawley, Broxuridine, Lipopolysaccharide, Nonsteroid antiinflammatory agent, Animal cell, Animal experiment, Animal model, Animal tissue, Article, Controlled study, Heat sensitivity, Nervous system development, Nervous system inflammation, Neural stem cell, Nonhuman, Priority journal, Rat, Subgranular zone, Animal, Drug effect, Intracerebroventricular drug administration, Sprague dawley rat