The role of adipokines in gestational diabetes mellitus
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Abstract
Gestational diabetes mellitus (GDM) is a complication of pregnancy that is characterized by impaired glucose tolerance with onset or first recognition during pregnancy. The reported prevalence of GDM varies between 0.6% and 20% of pregnancies depending on screening method, gestational age and the population studied. GDM is characterized by pancreatic β-cell function that is insufficient to meet the body's insulin needs. Available evidence suggests that β-cell defects in GDM result from the same spectrum of causes that underline hyperglycemia in general, including autoimmune disease, monogenic causes and insulin resistance. Adipokines are proteins secreted from the adipocytes and are believed to have a metabolic influence. Our review suggests that, in GDM, various adipokines, mainly leptin and adiponectin, are dysregulated. These two adipokines might have both prognostic and pathophysiological significance in this disease. © 2015, The Author(s),. All rights reserved.
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Adipokines, Adiponectin, Gestational diabetes, Insulin resistance, Leptin, Β cell, Adipocytokine, Chorionic gonadotropin, Interleukin 1, Interleukin 6, Nicotinamide phosphoribosyltransferase, Resistin, Retinol binding protein 4, Transcription factor 7 like 2, Tumor necrosis factor alpha, Cell proliferation, Glucose metabolism, Glucose tolerance, Hyperglycemia, Insulin blood level, Insulin release, Insulin sensitivity, Metabolic regulation, Pancreas islet beta cell, Pancreas islet cell function, Pathogenesis, Pregnancy diabetes mellitus, Pregnant woman, Priority journal, Protein expression, Review