Photochemical Preparation of 1,2-Dihydro-3 H-indazol-3-ones in Aqueous Solvent at Room Temperature

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dc.contributor.authorZhu, Jie S.
dc.contributor.authorKraemer, Niklas
dc.contributor.authorLi, Clarabella J.
dc.contributor.authorHaddadin, Makhluf J.
dc.contributor.authorKurth, Mark J.
dc.contributor.departmentDepartment of Chemistry
dc.contributor.facultyFaculty of Arts and Sciences (FAS)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:22:00Z
dc.date.available2025-01-24T11:22:00Z
dc.date.issued2018
dc.description.abstracto-Nitrosobenzaldehyde is a reactive intermediate useful in the synthesis of nitrogen heterocycles. Previous strategies for using o-nitrosobenzaldehyde involve its isolation via chromatography and/or formation under harsh conditions. Herein, this intermediate was photochemically generated in situ from o-nitrobenzyl alcohols in a mild, efficient manner for the construction of 1,2-dihydro-3H-indazol-3-ones using an aqueous solvent at room temperature. This convenient reaction offers several advantages over reported methods. The commercially available photoreactor employed 3 × 18 W bulbs outputting broad emission above 365 nm. © 2018 American Chemical Society.
dc.identifier.doihttps://doi.org/10.1021/acs.joc.8b02356
dc.identifier.eid2-s2.0-85058517989
dc.identifier.pmid30468072
dc.identifier.urihttp://hdl.handle.net/10938/25399
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofJournal of Organic Chemistry
dc.sourceScopus
dc.subjectCatalysis
dc.subjectIndazoles
dc.subjectPhotochemical processes
dc.subjectSolvents
dc.subjectTemperature
dc.subjectWater
dc.subjectChemistry
dc.subject1,2 dihydro 3h indazol 3 one derivative
dc.subject2 nitrobenzyl alcohol
dc.subjectAlcohol derivative
dc.subjectIndazole derivative
dc.subjectUnclassified drug
dc.subjectSolvent
dc.subjectAqueous solvents
dc.subjectNitrogen heterocycles
dc.subjectPhotochemical preparation
dc.subjectPhotoreactors
dc.subjectReactive intermediate
dc.subjectAqueous solution
dc.subjectArticle
dc.subjectLight
dc.subjectPhotochemistry
dc.subjectReaction analysis
dc.subjectReaction optimization
dc.subjectRoom temperature
dc.subjectOrganic compounds
dc.titlePhotochemical Preparation of 1,2-Dihydro-3 H-indazol-3-ones in Aqueous Solvent at Room Temperature
dc.typeArticle

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