ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma

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dc.contributor.authorJabbour, Mark N.
dc.contributor.authorSeoud, Muhieddine A.F.
dc.contributor.authorAl-Ahmadie, Hikmat A.
dc.contributor.authorAbdul-Karim, Fadi William
dc.contributor.authorZaatari, Ghazi S.
dc.contributor.departmentPathology and Laboratory Medicine
dc.contributor.departmentObstetrics and Gynecology
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:09:48Z
dc.date.available2025-01-24T12:09:48Z
dc.date.issued2014
dc.description.abstractAlveolar soft part sarcoma of the vulvovaginal region is limited to only 8 reported vaginal cases and 1 vulvar case in the English literature. The histogenesis of the tumor remains intriguing with postulates favoring a myogenic versus nonmyogenic origin. A reciprocal translocation for ASPL-TFE3 gene fusion, frequently detected in ∼90% of cases, combined with TFE3 protein immunoexpression are highly sensitive and specific methods for diagnostic confirmation. The current report describes a unique case of vulvovaginal alveolar soft part sarcoma showing the classic morphologic features with documentation of TFE3 protein expression and the ASPL-TFE3 gene rearrangement. Furthermore, a brief review of the literature of vulvar and vaginal alveolar soft part sarcoma cases with the various treatment modalities is outlined. © 2014 International Society of Gynecological Pathologists.
dc.identifier.doihttps://doi.org/10.1097/PGP.0b013e318290407c
dc.identifier.eid2-s2.0-84898599018
dc.identifier.pmid24681737
dc.identifier.urihttp://hdl.handle.net/10938/32128
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofInternational Journal of Gynecological Pathology
dc.sourceScopus
dc.subjectAlveolar soft part sarcoma
dc.subjectAspl-tfe3 gene fusion
dc.subjectTfe3 protein
dc.subjectVagina
dc.subjectVulva
dc.subjectBasic helix-loop-helix leucine zipper transcription factors
dc.subjectFemale
dc.subjectGene expression regulation, neoplastic
dc.subjectHumans
dc.subjectOncogene proteins, fusion
dc.subjectSarcoma, alveolar soft part
dc.subjectTranslocation, genetic
dc.subjectVaginal neoplasms
dc.subjectVulvar neoplasms
dc.subjectYoung adult
dc.subjectMembrane protein
dc.subjectProtein tfe3
dc.subjectUnclassified drug
dc.subjectAspscr1 protein, human
dc.subjectBasic helix loop helix leucine zipper transcription factor
dc.subjectOncoprotein
dc.subjectTfe3 protein, human
dc.subjectAdult
dc.subjectArticle
dc.subjectAspl tfe3 gene
dc.subjectCancer radiotherapy
dc.subjectCase report
dc.subjectCesarean section
dc.subjectComputer assisted tomography
dc.subjectFusion gene
dc.subjectGene rearrangement
dc.subjectGene translocation
dc.subjectHistopathology
dc.subjectHuman
dc.subjectHuman tissue
dc.subjectImmunohistochemistry
dc.subjectLocal excision
dc.subjectPostoperative period
dc.subjectPriority journal
dc.subjectProtein expression
dc.subjectThird trimester pregnancy
dc.subjectVulvovaginal alveolar soft part sarcoma
dc.subjectGene expression regulation
dc.subjectGenetics
dc.subjectPathology
dc.subjectVagina tumor
dc.subjectVulva tumor
dc.titleASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma
dc.typeArticle

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