S100 proteins and the skin: A review
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Blackwell Publishing Ltd
Abstract
The structurally related, low-molecular weight S100 proteins constitute a family of proteins that possess a common basic structure allowing them to carry out a range of intracellular and extracellular functions. Unifying intracellular functions relate to regulation of proliferation, energy metabolism, calcium homeostasis, enzyme activities, cell growth and differentiation. Extracellular tasks, however, appear somewhat specific to select S100 members and include participation in innate and adaptive immune responses, tissue development and repair, and/or cell migration and chemotaxis. This review is an attempt to comprehensively summarize the function and expression of S100 proteins selectively expressed in normal skin and/or involved in diseased skin. © 2013 European Academy of Dermatology and Venereology.
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Keywords
Humans, S100 proteins, Skin physiological phenomena, Binding protein, Calcium binding protein, Calcyclin, Calgranulin a, Calgranulin b, Calvasculin, Dodecyl sulfate sodium, Petrolatum, Placenta protein, Polypeptide antibiotic agent, Protein s 100, Protein s 100a10, Protein s 100a13, Protein s 100a15, Protein s 100a2, Protein s 100a3, Protein s 100a5, Protein s 100p, Protein s100a1, Protein s100b, Psoriasin, S100a11 protein, S100a12 protein, Tumor suppressor protein, Unclassified drug, Actinic keratosis, Apoptosis, Breast cancer, Cancer prognosis, Cell proliferation, Cell survival, Chemotaxis, Cutaneous melanoma, Desmoplastic melanoma, Dysplastic nevus, Epidermis, Guttate psoriasis, Hair follicle, Histopathology, Human, Immunoreactivity, Juvenile melanoma, Keratinocyte, Langerhans cell histiocytosis, Metastatic melanoma, Nonhuman, Placenta, Priority journal, Protein conformation, Protein expression, Protein function, Protein phosphorylation, Protein structure, Psoriasis, Psoriasis vulgaris, Review, Rhabdomyosarcoma, Sezary syndrome, Skin, Skin disease, Skin epithelium, Squamous cell carcinoma, Structural homology, Functions of the skin and its appendages, Physiology