Synthesis and characterization of menadione analogues and hydrazidoethyl-methyl-pyrimidine derivatives -

Abstract

1,4-Naphthoquinone possesses the quinone core which is reportedly essential for biological activity. Naphthoquinones, in general, have been reported to possess a variety of pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic and anticancer effects. Our interest in 1,4-naphthoquinone was fortified by literature reports that describe the anticancer activity of several thymoquinone derivatives. In this study, we report the synthesis of a new series of novel menadione-hydrazone conjugates by reaction of naphthoquinones with several aliphatic hydrazides. We synthesized a series of analogous menadione hydrazones and aim to evaluate their biological activity in comparison to the parent naphthoquinone molecule. Modified oligonucleotides have a plethora of industrial and synthetic applications. The hypothesis underlying this research project is that N,N-diallyl-N’-acylhydrazine derivatives can be cyclopolymerized more efficiently in comparison to the diallylamine derivatives. We successfully synthesized hydrazidoethyl-methyl-pyrimidine based (uracil, thymine) derivatives of N,N-diallyl-N’-hydrazine.