Intravitreal Adalimumab in Active Noninfectious Uveitis: A Pilot Study
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Taylor and Francis Ltd
Abstract
Abstract: Purpose: To evaluate the short-term efficacy of intravitreal adalimumab (IVA) for the treatment of eyes with active noninfectious uveitis. Methods: Consecutive eyes with active noninfectious uveitis were injected with IVA at 0, 2, then every 4 weeks for total of 26 weeks. Results: Six out of 7 patients (12 of 13 eyes) completed 26 weeks of treatment. One patient (1 eye) failed treatment. Seven out of 12 eyes had improvement of ≥2 ETDRS lines. Three out of three eyes had resolution of anterior chamber cells. And 9 of 10 eyes with vitreous haze had zero haze at 26 weeks. Five out of 8 eyes with macular edema had complete resolution. Median fluorescein angiography score improved from 14 to 4 on last follow-up. Conclusions: IVA was effective in controlling the inflammation, decreasing the macular edema, and improving the best corrected visual acuity in the majority of eyes in this series. © 2014 Rola N. Hamam, Anita W. Barikian, Rafic S. Antonios, Marwan R. Abdulaal, Ramzi M. Alameddine, Georges El Mollayess, and Ahmad M. Mansour.
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Adalimumab, Intravitreal adalimumab, Noninfectious uveitis, Uveitis treatment, Adult, Anterior chamber, Anti-inflammatory agents, Eye infections, Female, Fluorescein angiography, Humans, Intravitreal injections, Macular edema, Male, Middle aged, Pilot projects, Prospective studies, Tomography, optical coherence, Treatment outcome, Tumor necrosis factor-alpha, Uveitis, Visual acuity, Vitreous body, Young adult, Alpha2a interferon, Azathioprine, Cyclosporin, Infliximab, Methotrexate, Mycophenolic acid, Antiinflammatory agent, Tumor necrosis factor, Active noninfectious uveitis, Anterior eye chamber, Article, Behcet disease, Capillary leak syndrome, Clinical article, Clinical trial, Drug efficacy, Drug treatment failure, Electroretinography, Eye inflammation, Fluorescence angiography, Follow up, Human, Idiopathic disease, Immunosuppressive treatment, Off label drug use, Open study, Optic disk, Optical coherence tomography, Outcome assessment, Pilot study, Prospective study, Relapse, Retina capillary, Retina ischemia, Antagonists and inhibitors, Diagnostic imaging, Drug effects, Intravitreal drug administration, Pathology, Pathophysiology, Physiology