Hypercoagulability and Vascular Disease
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W.B. Saunders
Abstract
The presence of a high incidence of thrombotic events, mainly in nontransfusion-dependent β-thalassemia syndromes, has led to the identification of a hypercoagulable state in thalassemia patients. This article highlights the mechanisms leading to hypercoagulability in thalassemia. It also discusses the clinical experience and available evidence on prevention and management approaches. © 2017 Elsevier Inc.
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Keywords
Cerebrovascular disease, Hypercoagulable state, Pulmonary hypertension, Thrombosis, Disease management, Humans, Thalassemia, Thrombophilia, Vascular diseases, Acetylsalicylic acid, Anticoagulant agent, Beta thalassemia, Blood transfusion, Endothelial dysfunction, Erythrocyte, High risk patient, Human, Hypercoagulability, Magnetic resonance angiography, Nonhuman, Pathophysiology, Personalized medicine, Positron emission tomography, Positron emission tomography-computed tomography, Primary prevention, Priority journal, Review, Secondary prevention, Splenectomy, Thalassemia intermedia, Thalassemia major, Thermogenesis, Thrombocyte activation, Transcranial doppler ultrasonography, Vascular disease, Vascular endothelium, Complication