Prevalence and molecular epidemiology of carbapenem-resistant Gram-negative bacilli and their resistance determinants in the Eastern Mediterranean Region over the last decade

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dc.contributor.authorSleiman, Ahmad
dc.contributor.authorAbou Fayad, Antoine G.
dc.contributor.authorBanna, Hanin S.
dc.contributor.authorMatar, Ghassan
dc.contributor.departmentExperimental Pathology, Microbiology, and Immunology
dc.contributor.departmentSpecialized Clinical Programs and Services
dc.contributor.departmentCenter for Infectious Diseases Research
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:39:09Z
dc.date.available2025-01-24T11:39:09Z
dc.date.issued2021
dc.description.abstractCarbapenem resistance in Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa is increasing worldwide, which has led the World Health Organization (WHO) to list these bacteria in the critical priority pathogens group. Infections by such pathogens pose a serious threat to hospitalised patients and are associated with clinical and economic consequences. What worsens the case is the weak pipeline of available antimicrobial agents to treat such infections and the absence of new drugs. The aim of this review was to shed light on all studies tackling carbapenem resistance in Enterobacteriaceae, A. baumannii and P. aeruginosa in the Eastern Mediterranean region, with indication for each country, description of studies timeline, prevalence of carbapenem resistance, and carbapenem resistance-encoding genes detected in these countries. © 2021
dc.identifier.doihttps://doi.org/10.1016/j.jgar.2021.02.033
dc.identifier.eid2-s2.0-85104795824
dc.identifier.pmid33812049
dc.identifier.urihttp://hdl.handle.net/10938/29193
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofJournal of Global Antimicrobial Resistance
dc.sourceScopus
dc.subjectAcinetobacter baumannii
dc.subjectCarbapenem resistance
dc.subjectEnterobacteriaceae
dc.subjectPseudomonas aeruginosa
dc.subjectAnti-bacterial agents
dc.subjectCarbapenems
dc.subjectHumans
dc.subjectMediterranean region
dc.subjectMolecular epidemiology
dc.subjectPrevalence
dc.subjectCarbapenem
dc.subjectAntiinfective agent
dc.subjectCarbapenem derivative
dc.subjectAfghanistan
dc.subjectBacterial gene
dc.subjectBacterium isolate
dc.subjectBahrain
dc.subjectCarbapenem resistant acinetobacter baumannii
dc.subjectCarbapenem resistant pseudomonas aeruginosa
dc.subjectCarbapenem-resistant enterobacteriaceae
dc.subjectDjibouti
dc.subjectEgypt
dc.subjectGenetic resistance
dc.subjectGeographic distribution
dc.subjectHuman
dc.subjectInformation retrieval
dc.subjectIran
dc.subjectIraq
dc.subjectJordan
dc.subjectKuwait
dc.subjectLebanon
dc.subjectLibyan arab jamahiriya
dc.subjectMedline
dc.subjectMorocco
dc.subjectNonhuman
dc.subjectOman
dc.subjectPakistan
dc.subjectPalestine
dc.subjectPriority journal
dc.subjectPublication
dc.subjectQatar
dc.subjectReview
dc.subjectSaudi arabia
dc.subjectScopus
dc.subjectSearch engine
dc.subjectSomalia
dc.subjectSouthern europe
dc.subjectSudan
dc.subjectSyrian arab republic
dc.subjectTimeliness (data)
dc.subjectTunisia
dc.subjectUnited arab emirates
dc.subjectYemen
dc.subjectEpidemiology
dc.titlePrevalence and molecular epidemiology of carbapenem-resistant Gram-negative bacilli and their resistance determinants in the Eastern Mediterranean Region over the last decade
dc.typeReview

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