Adult T-cell leukemia/lymphoma in a Caucasian patient after sexual transmission of human T-cell lymphotropic virus type 1
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Oxford University Press
Abstract
Adult T-cell leukemia/lymphoma (ATLL), a T-cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1), develops in the majority of cases in individuals who were infected with HTLV-1 as young children, by their mother during prolonged breastfeeding. We report the case of a Caucasian French man, whose parents were HTLV-1-seronegative and who developed ATLL after HTLV-1 sexual transmission by a Cameroonian woman. This hypothesis was corroborated by genotyping of the patient's virus, which revealed an HTLV-1B strain, found only in Central Africa, especially in Cameroon. Thus, ATLL may develop after HTLV-1 infection during adulthood, outside breastfeeding. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Societyof America.
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Atll, Htlv-1, Htlv-1 transmission, Lymphoma, Viral genotyping, Alpha interferon, Corticosteroid, Zidovudine, Adult, Agglutination test, Article, Case report, Caucasian, Gene rearrangement, Genotype, Human, Human tissue, Immunophenotyping, Lymphocyte, Male, Nonhuman, Photochemotherapy, Priority journal, Real time polymerase chain reaction, Sexual transmission, Simian immunodeficiency virus, Skin biopsy, T cell leukemia, Western blotting