Propofol use in children: Updates and controversies
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Edizioni Minerva Medica
Abstract
Advantages of propofol use in children may include less airway complications, less emergence agitation, and less postoperative behavioral changes. However, needle phobia and the complexity of total intravenous anesthesia set-up, as well as the pharmacokinetic and pharmacodynamic restrictions may limit the wide use of propofol-based anesthesia in the form of total intravenous anesthesia. Furthermore, pediatric infusion models and monitoring techniques are not fully validated yet. The choice of anesthesia type in children seems to be the result of a complex interplay between many factors related to the patient and the provider as well as logistic and operational factors that contribute to the decision-making process. Propofol has earned its place as a valuable choice in pediatric anesthesia. In addition, propofol and inhalation anesthesia should not be looked at as mutually exclusive; a combination of both may sometimes be the best approach to complex clinical dilemmas. © 2019 EDIZIONI MINERVA MEDICA.
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Keywords
Anesthesia, Pediatrics, Propofol, Sevoflurane, Anesthesia, general, Anesthesia, inhalation, Child, Humans, Hypnotics and sedatives, Central muscle relaxant, Creatine kinase, Dexmedetomidine, Ketamine, Messenger rna, Narcotic analgesic agent, Neuromuscular blocking agent, Sufentanil, Hypnotic sedative agent, Airway complication, Algorithm, Anesthesia induction, Bispectral index, Brain surgery, Decision making, Disease severity, Drug delivery system, Electroencephalography, Emergence agitation, Endotracheal intubation, Epidural anesthesia, Epileptic discharge, Epileptic state, Expiration reflex, Foreign body, Human, Hyperalgesia, Hypoxia, Incidence, Inhalation anesthesia, Lean body weight, Nuclear magnetic resonance imaging, Obesity, Oculocardiac reflex, Oxidative phosphorylation, Pathology, Perioperative period, Pharmacokinetic parameters, Postoperative analgesia, Recovery room, Respiratory drive, Review, Rhabdomyolysis, Sedation, Somatosensory cortex, Volume of distribution, General anesthesia