The effect of premedication with peppermint oil capsules (Colpermin) prior to colonoscopy: A double blind randomized placebo-controlled trial
Loading...
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd
Abstract
Background and study aims: Colonoscopy is the cornerstone of diagnosing colonic diseases. Investigators have evaluated the effectiveness of antispasmodic agents in colonoscopy with conflicting evidence. The aim of this study is to determine the efficacy of enteric coated peppermint oil capsules (Colpermin®), an antispasmodic agent, on outcomes during colonoscopy. Patients and methods: A total of 80 patients undergoing elective colonoscopy were recruited and randomized in a double blinded fashion to receive either placebo or peppermint oil capsules administered 4 h prior to the procedure. Results: Peppermint oil capsules did not affect caecal intubation time when compared with placebo. Patients’ tolerance, endoscopist's satisfaction and demand on sedation were also not affected. Conclusion: This randomized controlled trial does not support the routine use of peppermint oil capsules prior to colonoscopy as a tool for procedure optimization, and patients’ and endoscopist's satisfaction. © 2017 Pan-Arab Association of Gastroenterology
Description
Keywords
Colonic spasm, Colonoscopy, Peppermint oil, Premedication, Adult, Aged, Aged, 80 and over, Capsules, Double-blind method, Female, Humans, Lebanon, Male, Middle aged, Parasympatholytics, Plant oils, Tablets, enteric-coated, Midazolam, Pethidine, Cholinergic receptor blocking agent, Vegetable oil, Article, Colon disease, Controlled study, Double blind procedure, Drug capsule, Drug effect, Drug efficacy, Human, Intestinal spasm, Intestine preparation, Major clinical study, Pain assessment, Priority journal, Randomized controlled trial, Sedation, Spasmolysis, Enteric coated tablet, Microcapsule, Very elderly