Update on the management of colchicine resistant Familial Mediterranean Fever (FMF)
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BioMed Central Ltd.
Abstract
Background: Familial Mediterranean Fever (FMF), an autoinflammatory disease, is characterized by self-limited inflammatory attacks of fever and polyserositis along with high acute phase response. Although colchicine remains the mainstay in treatment, intolerance and resistance in a certain portion of patients have been posing a problem for physicians. Main body: Like many autoimmune and autoinflammatory diseases, many colchicine-resistant or intolerant FMF cases have been successfully treated with biologics. In addition, many studies have tested the efficacy of biologics in treating FMF manifestations. Conclusion: Since carriers of FMF show significantly elevated levels of serum TNF alpha, IL-1, and IL-6, FMF patients who failed colchicine were successfully treated with anti IL-1, anti IL-6, or TNF inhibitors drugs. It is best to use colchicine in combination with biologics. © 2019 The Author(s).
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Keywords
Autoinflammatory diseases, Biologics, Colchicine resistance, Familial mediterranean fever, Animals, Colchicine, Humans, Interleukin-1, Interleukin-6, Tumor necrosis factor-alpha, Adalimumab, Anakinra, Canakinumab, Corticosteroid, Etanercept, Hydroxychloroquine, Infliximab, Interleukin 1, Interleukin 6, Leflunomide, Methotrexate, Mycophenolic acid, Placebo, Prednisolone, Prednisone, Pyrin, Rilonacept, Salazosulfapyridine, Steroid, Tocilizumab, Tofacitinib, Tumor necrosis factor, Allergy, Alopecia, Amyloidosis, Autoimmune disease, Azoospermia, Chronic arthritis, Cinca syndrome, Diarrhea, Drug dose reduction, Drug efficacy, Drug megadose, Drug safety, Drug substitution, Drug withdrawal, Familial cold autoinflammatory syndrome, Gastrointestinal symptom, Gene mutation, Heterozygote, Human, Injection site pain, Injection site reaction, Juvenile rheumatoid arthritis, Low drug dose, Maximum tolerated dose, Mefv gene, Muckle wells syndrome, Pathogenesis, Patient compliance, Proteinuria, Relapse, Remission, Respiratory tract infection, Review, Rheumatoid arthritis, Systemic lupus erythematosus, Urinary tract infection, Viral gastroenteritis, Animal, Blood