Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers
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W.B. Saunders Ltd
Abstract
Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions. © 2018 Elsevier Ltd
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Keywords
Biomarkers, Bipolar disorder, Circadian rhythm sleep-wake disorders, Delayed sleep wake phase disorder, Melatonin, Mood disorder, Sleep disorders, Humans, Sleep disorders, circadian rhythm, Adenosine triphosphatase (potassium sodium), Agomelatine, Aralkylamine acetyltransferase, Casein kinase idelta, Cryptochrome 1, Cryptochrome 2, Cyclic amp responsive element binding protein, Glycogen synthase kinase 3beta, Lithium, Melatonin 1 receptor, Melatonin 2 receptor, Per1 protein, Per2 protein, Retinoic acid receptor, Transcription factor arntl, Transcription factor clock, Valproic acid, Biological marker, Behavior, Circadian rhythm sleep disorder, Delayed sleep wake phase syndrome, Depression, Disease marker, Genetic association, Human, Nonhuman, Pathogenesis, Pathophysiology, Phototherapy, Prognosis, Review, Systematic review, Variable number of tandem repeat, Complication, Psychology