Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

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dc.contributor.authorTalih, Farid Ramzi
dc.contributor.authorGebara, Nour Y.
dc.contributor.authorAndary, Farah S.
dc.contributor.authorMondello, Stefania
dc.contributor.authorKobeissy, Firas H.
dc.contributor.authorFerri, Raffaele
dc.contributor.departmentPsychiatry
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:11:53Z
dc.date.available2025-01-24T12:11:53Z
dc.date.issued2018
dc.description.abstractCircadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions. © 2018 Elsevier Ltd
dc.identifier.doihttps://doi.org/10.1016/j.smrv.2018.02.002
dc.identifier.eid2-s2.0-85043263196
dc.identifier.pmid29534856
dc.identifier.urihttp://hdl.handle.net/10938/32605
dc.language.isoen
dc.publisherW.B. Saunders Ltd
dc.relation.ispartofSleep Medicine Reviews
dc.sourceScopus
dc.subjectBiomarkers
dc.subjectBipolar disorder
dc.subjectCircadian rhythm sleep-wake disorders
dc.subjectDelayed sleep wake phase disorder
dc.subjectMelatonin
dc.subjectMood disorder
dc.subjectSleep disorders
dc.subjectHumans
dc.subjectSleep disorders, circadian rhythm
dc.subjectAdenosine triphosphatase (potassium sodium)
dc.subjectAgomelatine
dc.subjectAralkylamine acetyltransferase
dc.subjectCasein kinase idelta
dc.subjectCryptochrome 1
dc.subjectCryptochrome 2
dc.subjectCyclic amp responsive element binding protein
dc.subjectGlycogen synthase kinase 3beta
dc.subjectLithium
dc.subjectMelatonin 1 receptor
dc.subjectMelatonin 2 receptor
dc.subjectPer1 protein
dc.subjectPer2 protein
dc.subjectRetinoic acid receptor
dc.subjectTranscription factor arntl
dc.subjectTranscription factor clock
dc.subjectValproic acid
dc.subjectBiological marker
dc.subjectBehavior
dc.subjectCircadian rhythm sleep disorder
dc.subjectDelayed sleep wake phase syndrome
dc.subjectDepression
dc.subjectDisease marker
dc.subjectGenetic association
dc.subjectHuman
dc.subjectNonhuman
dc.subjectPathogenesis
dc.subjectPathophysiology
dc.subjectPhototherapy
dc.subjectPrognosis
dc.subjectReview
dc.subjectSystematic review
dc.subjectVariable number of tandem repeat
dc.subjectComplication
dc.subjectPsychology
dc.titleDelayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers
dc.typeReview

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