Latest updates on cellular and molecular biomarkers of gliomas
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Frontiers Media S.A.
Abstract
Gliomas are the most common central nervous system malignancies, compromising almost 80% of all brain tumors and is associated with significant mortality. The classification of gliomas has shifted from basic histological perspective to one that is based on molecular biomarkers. Treatment of this type of tumors consists currently of surgery, chemotherapy and radiation therapy. During the past years, there was a limited development of effective glioma diagnostics and therapeutics due to multiple factors including the presence of blood-brain barrier and the heterogeneity of this type of tumors. Currently, it is necessary to highlight the advantage of molecular diagnosis of gliomas to develop patient targeted therapies based on multiple oncogenic pathway. In this review, we will evaluate the development of cellular and molecular biomarkers for the diagnosis of gliomas and the impact of these diagnostic tools for better tailored and targeted therapies. Copyright © 2022 Bou Zerdan, Atoui, Hijazi, Basbous, Abou Zeidane, Alame and Assi.
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Keywords
Biomarkers, Circulating tumor cells, Circulating tumor dna, Gliomas, Immune microenvironment, Biological marker, Chondroitin sulfate, Microrna, Microsphere, Molecular marker, Sunitinib, Telomerase reverse transcriptase, Temozolomide, Vimentin, Akt/mtor signaling, Angiogenesis, Apoptosis, Astrocyte, Blood brain barrier, Brain tumor, Cancer chemotherapy, Cancer screening, Cancer therapy, Cell proliferation, Cellular immunity, Central nervous system, Chemosensitivity, Cytotoxicity, Dna methylation, Dna replication, Flow cytometry, Gene amplification, Gene expression, Genetic parameters, Genotyping, Glioblastoma, Glioma, Histone modification, Human, Immune response, Karnofsky performance status, Liquid biopsy, Microenvironment, Molecular diagnosis, Molecularly targeted therapy, Mouse, Nonhuman, Oligodendroglioma, Progression free survival, Review, Signal transduction, Tumor growth, Ubiquitination, Upregulation, Whole genome sequencing