Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: Systematic review
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Future Medicine Ltd.
Abstract
Aim: This systematic review summarizes the clinical data on focal therapy (FT) when used alone as definitive therapy for primary prostate cancer (PCA). Methods: The protocol is detailed in the online PROSPERO database, registration No. CRD42014014765. Articles evaluating any form of FT alone as a definitive treatment for PCA in adult male patients were included. Results: Of 10,419 identified articles, 10,401 were excluded, and thus leaving 18 for analysis. In total, 2288 patients were treated using seven modalities. The outcomes of FT in PCA seem to be similar to those observed with whole gland therapy and with fewer side effects. Conclusion: Further research, including prospective randomized trials, is warranted to elucidate the potential advantages of focal radiation techniques for treating PCA. © 2016 Future Medicine Ltd.
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Brachytherapy, Cryotherapy, Focal therapy, Hifu, Prostate cancer, Sbrt, Ablation techniques, Combined modality therapy, Humans, Male, Neoplasm staging, Prostatic neoplasms, Treatment outcome, Ablation therapy, Age distribution, Cancer mortality, Dysuria, External beam radiotherapy, Follow up, Hematuria, High intensity focused ultrasound, Human, Intention to treat analysis, Laser surgery, Microwave thermotherapy, Outcome assessment, Personalized medicine, Photothermal therapy, Progression free survival, Prostatitis, Radiofrequency ablation, Rectum fistula, Review, Sexual dysfunction, Systematic review, Urethra stenosis, Urinary tract infection, Urine incontinence, Urine retention, Adverse effects, Cancer staging, Meta analysis, Mortality, Multimodality cancer therapy, Procedures