Successful treatment of severe aplastic anemia with syngeneic stem cell transplantation in the setting of active disseminated mucormycosis

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dc.contributor.authorEl-Cheikh, Jean
dc.contributor.authorAtoui, Ali
dc.contributor.authorMoukalled, Nour M.
dc.contributor.authorGhaoui, Nohra
dc.contributor.authorEl Darsa, Haidar
dc.contributor.authorKanj, Souha S.
dc.contributor.authorBazarbachi, Ali Abdul Hamid
dc.contributor.departmentSpecialized Clinical Programs and Services
dc.contributor.departmentInternal Medicine
dc.contributor.departmentBone Marrow Transplantation (BMT) Program
dc.contributor.departmentInfectious Diseases Services and Programs
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:20:28Z
dc.date.available2025-01-24T12:20:28Z
dc.date.issued2019
dc.description.abstractSevere aplastic anemia (SAA) is a hematological disease resulting in pancytopenia due to bone marrow failure. Treatment consists of immunosppressive therapy, or allo-SCT. Patients with aplastic anemia are predisposed to invasive fungal infections due to mucormycosis. Till now, syngeneic SCT in the context of active mucormycosis infection for patients with severe aplastic anemia is lacking in the literature. Here, we report a case of severe aplastic anemia with disseminated mucormycosis infection undergoing syngeneic transplant. © 2019 The Authors
dc.identifier.doihttps://doi.org/10.1016/j.mmcr.2019.01.001
dc.identifier.eid2-s2.0-85060093158
dc.identifier.urihttp://hdl.handle.net/10938/34302
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofMedical Mycology Case Reports
dc.sourceScopus
dc.subjectMucormycosis
dc.subjectSevere aplastic anemia
dc.subjectSyngeneic transplantation
dc.subjectAmphotericin b lipid complex
dc.subjectCd34 antigen
dc.subjectClarithromycin
dc.subjectContrast medium
dc.subjectCyanocobalamin
dc.subjectCyclosporine
dc.subjectEltrombopag
dc.subjectErythropoietin
dc.subjectFludarabine
dc.subjectGranulocyte colony stimulating factor receptor
dc.subjectHemoglobin
dc.subjectInsulin
dc.subjectLinezolid
dc.subjectPiperacillin plus tazobactam
dc.subjectPosaconazole
dc.subjectThymocyte antibody
dc.subjectVoriconazole
dc.subjectAbdominal radiography
dc.subjectAbscess drainage
dc.subjectAdd on therapy
dc.subjectAdult
dc.subjectAntibiotic therapy
dc.subjectAntifungal therapy
dc.subjectAplastic anemia
dc.subjectArticle
dc.subjectBacterial growth
dc.subjectBorrelia infection
dc.subjectBrain tomography
dc.subjectBronchoalveolar lavage fluid
dc.subjectCandida tropicalis
dc.subjectCandidiasis
dc.subjectCase report
dc.subjectChronic sinusitis
dc.subjectClinical article
dc.subjectCombination drug therapy
dc.subjectComputer assisted tomography
dc.subjectConsciousness
dc.subjectConsciousness disorder
dc.subjectDebridement
dc.subjectDisease activity
dc.subjectDisease severity
dc.subjectDrug substitution
dc.subjectDrug withdrawal
dc.subjectEnterococcal infection
dc.subjectEnterococcus faecalis
dc.subjectEpistaxis
dc.subjectErythrocyte transfusion
dc.subjectFever
dc.subjectFungus hyphae
dc.subjectGraft versus host reaction
dc.subjectHaemophilus parainfluenzae
dc.subjectHematocrit
dc.subjectHemoglobin blood level
dc.subjectHuman
dc.subjectImage guided biopsy
dc.subjectImmunosuppressive treatment
dc.subjectInguinal region
dc.subjectInsulin dependent diabetes mellitus
dc.subjectInsulin treatment
dc.subjectIraq
dc.subjectLethargy
dc.subjectLeukocyte count
dc.subjectLung biopsy
dc.subjectLung nodule
dc.subjectMagnetic resonance venography
dc.subjectMale
dc.subjectMedical history
dc.subjectMethicillin resistant staphylococcus aureus
dc.subjectMycosis
dc.subjectNeuroimaging
dc.subjectNeutropenia
dc.subjectPancytopenia
dc.subjectParoxysmal nocturnal hemoglobinuria
dc.subjectPelvis radiography
dc.subjectPlatelet count
dc.subjectPriority journal
dc.subjectRecurrent disease
dc.subjectRight lung
dc.subjectSomnolence
dc.subjectSpleen abscess
dc.subjectStem cell transplantation
dc.subjectSystemic mycosis
dc.subjectThorax radiography
dc.subjectThrombocyte transfusion
dc.subjectTransplantation conditioning
dc.subjectVitamin blood level
dc.subjectWhole body radiation
dc.titleSuccessful treatment of severe aplastic anemia with syngeneic stem cell transplantation in the setting of active disseminated mucormycosis
dc.typeArticle

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