Diversity of sequence types and impact of fitness cost among carbapenem-resistant acinetobacter baumannii isolates from Tripoli, Libya
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American Society for Microbiology
Abstract
We investigated the molecular epidemiology of 21 carbapenem-resistant Acinetobacter baumannii isolates from Libya and assessed their relative fitness. Core genome multilocus sequence typing (MLST) revealed five interhospital transmission clusters. Three clusters were associated with the international clones (IC) IC1, IC2, and IC7. Carbapenem-resistance was associated with blaOXA-23, blaGES-11, or blaNDM-1. Compared to that of A. baumannii DSM 30008, the doubling time was similar over 10 h, but after 16 h, half the isolates grew to higher densities, suggesting a fitness advantage. Copyright © 2021 American Society for Microbiology. All Rights Reserved.
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Acinetobacter baumannii, Antimicrobial resistance, Carbapenems, Fitness cost, Acinetobacter infections, Anti-bacterial agents, Bacterial proteins, Beta-lactamases, Humans, Libya, Microbial sensitivity tests, Multilocus sequence typing, Amikacin, Beta lactamase, Beta lactamase ges 11, Beta lactamase ndm 1, Beta lactamase oxa 23, Carbapenem, Cefepime, Ceftazidime, Ciprofloxacin, Colistin, Cotrimoxazole, Gentamicin, Imipenem, Levofloxacin, Meropenem, Piperacillin plus tazobactam, Tetracycline, Unclassified drug, Antiinfective agent, Bacterial protein, Carbapenem derivative, Adult, Aged, Antibiotic sensitivity, Article, Bacterial genome, Bacterial strain, Bacterium isolate, Carbapenem resistance, Carbapenem resistant acinetobacter baumannii, Child, Clinical article, Clone, Controlled study, Cost, Female, Fitness, Gene cluster, Hospital patient, Human, Interhospital cooperation, Libyan arab jamahiriya, Male, Microbial diversity, Middle aged, Minimum inhibitory concentration, Molecular epidemiology, Multidrug resistance, Newborn, School child, Acinetobacter infection, Genetics, Microbial sensitivity test