Intravitreal Ziv-Aflibercept : Safety Analysis in Eyes Receiving More Than Ten Intravitreal Injections
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Taylor and Francis Ltd
Abstract
Purpose: To report the ocular and systemic adverse events in eyes receiving ≥10 intravitreal ziv-aflibercept (IVZ) injections. Methods: Medical records of patients who received ≥10 IVZ for various chorioretinal conditions with minimum follow up period of 12 months were retrospectively analysed. These eyes received standard dose of IVZ (1.25 mg/0.05 ml) on pro-re-nata (PRN) or treat and extend (T&E) protocol. The primary study outcome was ocular and systemic adverse events related to IVZ injections whereas secondary outcomes were change in best corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography (OCT) at last visit compared to baseline. Comparison of BCVA and CMT at baseline and final visit was done using paired t-test. Results: A total of 94 eyes which received a mean ± standard deviation (mean±SD = 14.4 ± 4.6) IVZ injections were studied. A total of 41 eyes were treatment naïve whereas 53 eyes received intravitreal injections in the past with last injection at least 3 months prior. Mean (±SD) follow up period was 26.7 ± 8.7 months. Ocular adverse events were limited with a case each of acute iridocyclitis, endophthalmitis, cataract progression and early epiretinal membrane formation. No systemic events were recorded within a month of IVZ injection. There was a significant improvement in BCVA (p = 0.001) and change in CMT (p = 0.001) at last visit. Conclusion: Ocular use of ziv-aflibercept is safe with limited ocular and systemic side effects. Multiple injections of IVZ can be used in various chorioretinal diseases over the long term. ©, © Taylor & Francis.
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Keywords
Diabetic macular edema (dme), Intravitreal ziv, aflibercept (ivz), Neovascular age related macular degeneration (n, amd), Retinal venous occlusion (rvo), Ziv, aflibercept, Aged, Angiogenesis inhibitors, Chorioretinitis, Choroid, Female, Fluorescein angiography, Follow-up studies, Fundus oculi, Humans, Intravitreal injections, Male, Receptors, vascular endothelial growth factor, Recombinant fusion proteins, Retina, Retrospective studies, Tomography, optical coherence, Treatment outcome, Aflibercept, Corticosteroid, Dexamethasone, Mydriatic agent, Triamcinolone acetonide, Angiogenesis inhibitor, Fusion protein, Vasculotropin receptor, Age related macular degeneration, Article, Best corrected visual acuity, Cataract, Cataract extraction, Central macular thickness, Central retina vein occlusion, Central serous retinopathy, Cohort analysis, Diabetic macular edema, Disease exacerbation, Drug safety, Endophthalmitis, Epiretinal membrane, Follow up, Human, Internal limiting membrane, Intraocular pressure, Iridocyclitis, Lens implantation, Major clinical study, Optical coherence tomography, Outcome assessment, Polypoidal choroidal vasculopathy, Priority journal, Retinal pigment epithelium, Retrospective study, Slit lamp microscopy, Clinical trial, Eye fundus, Fluorescence angiography, Intravitreal drug administration, Multicenter study, Pathology, Procedures