Kennedy’s disease: an under-recognized motor neuron disorder

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dc.contributor.authorMalek, Elia Gebran
dc.contributor.authorSalameh, Johnny S.
dc.contributor.authorMakki, Achraf
dc.contributor.departmentNeurology
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:07:38Z
dc.date.available2025-01-24T12:07:38Z
dc.date.issued2020
dc.description.abstractKennedy’s disease or spinal bulbar muscular atrophy is a rare, inherited and slowly progressive multisystem disease mostly manifesting with a motor neuron disease phenotype leading to disability. The slow progression, partial androgen insensitivity, electrophysiological evidence of sensory neuronopathy, and relatively spared central nervous system pathways help differentiate it from amyotrophic lateral sclerosis. To date, there is no treatment or cure with clinical care mainly focused on accurate diagnosis, symptom management, patient education, and genetic counselling. © 2020, Belgian Neurological Society.
dc.identifier.doihttps://doi.org/10.1007/s13760-020-01472-6
dc.identifier.eid2-s2.0-85089781266
dc.identifier.pmid32839928
dc.identifier.urihttp://hdl.handle.net/10938/31589
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofActa Neurologica Belgica
dc.sourceScopus
dc.subjectKennedy’s disease
dc.subjectMotor neuron disease
dc.subjectSpinal bulbar muscular atrophy
dc.subjectBulbo-spinal atrophy, x-linked
dc.subjectHumans
dc.subjectAndrogen receptor
dc.subjectBiological marker
dc.subjectEthambutol
dc.subjectFollitropin
dc.subjectLeuprorelin
dc.subjectLevodopa
dc.subjectLomustine
dc.subjectMitochondrial dna
dc.subjectPolyglutamine
dc.subjectAndrogen insensitivity syndrome
dc.subjectCognitive defect
dc.subjectDaily life activity
dc.subjectDisease severity
dc.subjectDysarthria
dc.subjectDysphonia
dc.subjectDystonia
dc.subjectElectromyography
dc.subjectElectrophysiology
dc.subjectExercise intensity
dc.subjectGene mutation
dc.subjectGenetic counseling
dc.subjectGrip strength
dc.subjectGynecomastia
dc.subjectHuman
dc.subjectHuntington chorea
dc.subjectKennedy disease
dc.subjectMini mental state examination
dc.subjectMorphometry
dc.subjectMotor evoked potential
dc.subjectMotor performance
dc.subjectMuscle action potential
dc.subjectMuscle atrophy
dc.subjectMuscle hypertrophy
dc.subjectMuscular dystrophy
dc.subjectMyalgia
dc.subjectMyelooptic neuropathy
dc.subjectNerve degeneration
dc.subjectNerve potential
dc.subjectNeuroimaging
dc.subjectNeuropsychological test
dc.subjectNuclear magnetic resonance imaging
dc.subjectParesthesia
dc.subjectParkinson disease
dc.subjectPatient education
dc.subjectPeriodic limb movement disorder
dc.subjectPhenotype
dc.subjectPleocytosis
dc.subjectPolysomnography
dc.subjectPrevalence
dc.subjectPrognosis
dc.subjectQuality of life
dc.subjectRem sleep
dc.subjectReview
dc.subjectSix minute walk test
dc.subjectSpine fracture
dc.subjectWhite matter
dc.titleKennedy’s disease: an under-recognized motor neuron disorder
dc.typeReview

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