Fibrotic Cystic Lung Disease Post Hematopoietic Stem Cell Transplant: Who is the Culprit?
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SAGE Publications Ltd
Abstract
Pulmonary complications post hematopoietic stem cell transplant (HSCT) are associated with poor outcomes and require extensive management depending on the etiology. They usually present in the form of bronchiolitis obliterans syndrome, interstitial pneumonitis, or drug toxicity that can lead to fibrosis. Scant data exists regarding diffuse cystic lung disease following HSCT, and the existing literature only mentions mild cystic changes. We present the case of a 25-year-old man with stage IVB Hodgkin’s lymphoma post allogeneic HSCT, who developed progressive traction bronchiectasis, with the appearance of extensive pulmonary cysts that followed significant fibrotic changes and discuss the possible etiologies behind it. © The Author(s) 2022.
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Keywords
Bronchiolitis obliterans, Graft versus host disease, Hematopoietic stem cell transplantation, Interstitial, Lung diseases, Bendamustine, Bleomycin, Brentuximab vedotin, Carboplatin, Cisplatin, Cotrimoxazole, Cytarabine, Dacarbazine, Dexamethasone, Doxorubicin, Etoposide, Fluorodeoxyglucose, Fluticasone furoate plus vilanterol, Ifosfamide, Levofloxacin, Meropenem, Moxifloxacin, Oseltamivir, Piperacillin plus tazobactam, Prednisone, Procalcitonin, Tiotropium bromide, Valaciclovir, Vinblastine, Voriconazole, Adolescent, Article, Backache, Bacterial pneumonia, Body weight loss, Bronchiectasis, Bronchoscopy, Cancer recurrence, Cancer regression, Cancer staging, Case report, Clinical article, Drug megadose, Erythema, Follow up, Forced expiratory volume, Forced vital capacity, Graft versus host reaction, Ground glass opacity, Hodgkin disease, Human, Human tissue, Influenza b, Lung aspergillosis, Lung fibrosis, Lung function test, Lung lavage, Maintenance therapy, Male, Multiple cycle treatment, Night sweat, Organizing pneumonia, Positron emission tomography, Protein blood level, Salvage therapy, Treatment duration, Treatment outcome, Treatment response, Wheezing, X-ray computed tomography