Post-transplant Lymphoproliferative Disease (PTLD) of The Larynx in an Adult With Kidney Transplant; A Case Report
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Mosby Inc.
Abstract
Post-transplant lymphoproliferative disease (PTLD) is a clinicopathologic entity characterized by an abnormal lymphocytic proliferation that occurs in immunosuppressed patients following organ transplantation. Several sites in the head and neck may be affected by PTLD with rare involvement of the larynx. Affected patients often present with symptoms and signs suggestive of a malignant lesion. Early diagnosis using histopathologic examination is paramount to prevent life-threatening airway compromise. The authors of this manuscript report a 52-year-old women, diagnosed case of renal failure for which she had undergone kidney transplant, who presented with symptoms of laryngeal PTLD. The clinical work-up and management of these cases is reviewed. © 2020
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Keywords
Dysphagia, Kidney transplant, Larynx, Post-transplant lymphoproliferative disease, Upper airway, Adult, Epstein-barr virus infections, Female, Humans, Kidney transplantation, Lymphoproliferative disorders, Middle aged, Alk protein, Cd20 antigen, Cd3 antigen, Cd5 antigen, Cd56 antigen, Mycophenolate mofetil, Rna, Tacrolimus, Transcription factor pax5, Tumor necrosis factor receptor superfamily member 8, Unclassified drug, Article, Case report, Cervical spine radiography, Clinical article, Computer assisted tomography, Disease duration, Epiglottis, Epiglottis tumor, Fiber optics, Follow up, Histopathology, Human, Human tissue, Immunosuppressive treatment, In situ hybridization, Kidney failure, Kidney graft, Larynx disorder, Lupus erythematosus nephritis, Lymphocytic infiltration, Medical history, Microlaryngoscopy, Posttransplant lymphoproliferative disease, Sore throat, Throat disease, Upper respiratory tract, Voice, Adverse event, Diagnostic imaging, Epstein barr virus infection, Lymphoproliferative disease