Ustekinumab successfully treats and maintains remission of pyostomatitis vegetans associated with Crohn's disease
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Oxford University Press
Abstract
Pyostomatitis vegetans (PV) is a rare inflammatory stomatitis often associated with inflammatory bowel diseases (IBD). Treatment of PV depends on the presence of coexisting IBD. To date, there have been no reports on the use of ustekinumab for PV. There have been recent cases on the use of ustekinumab for treatment of pyoderma gangrenosum and uveitis. We report the case of a 26-year-old female with moderately severe Crohn's disease (CD) and PV who was successfully treated with ustekinumab monotherapy. Since initiation of ustekinumab, she has been in clinical and biochemical remission from a CD and PV standpoint for the last 12 months. Lay Summary Pyostomatitis vegetans (PV) is a rare inflammatory condition of the mouth/lips that is associated with inflammatory bowel diseases (IBD). Treating underlying IBD helps control PV. We present the first case of Crohn's disease-associated PV that was successfully treated with ustekinumab. © 2020 Crohn's & Colitis Foundation. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation.
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Crohn's disease, Inflammatory bowel diseases, Pyostomatitis vegetans, Ustekinumab, Azathioprine, C reactive protein, Glucose 6 phosphate dehydrogenase, Hemoglobin, Mesalazine, Prednisone, Steroid, Abdominal pain, Abdominal tenderness, Acantholysis, Adult, Angioneurotic edema, Article, Body weight loss, Buccal mucosa, Case report, Chin, Clinical article, Colonoscopy, Crohn disease, Diarrhea, Differential diagnosis, Disease association, Erosion, Erythema, Female, Hard palate, Hemoglobin blood level, Human, Ileocecal valve, Ileum, Immunofluorescence, Infusion, Intestine ulcer, Intraepidermal acantholysis, Leukocyte count, Lip, Loose feces, Lower abdominal pain, Magnetic resonance enterography, Mean corpuscular volume, Monotherapy, Mouth pain, Neutrophil count, Orofacial granulomatosis, Pemphigus, Physical examination, Priority journal, Psoriasis, Pustule, Recurrent disease, Remission, Steroid therapy, Stomatitis, Swelling, Terminal ileum