Is the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literature
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Cambridge University Press
Abstract
Objectives: To study and review the short-and long-term effects of intranasal steroids on obstructive adenoids. Methods: In this prospective cohort study, 19 children previously treated with mometasone furoate for 3 months were contacted at 3, 6 and 12 months after cessation of treatment. Main outcome measures included: change in severity of nasal obstruction, allergic rhinitis and obstructive symptoms. A systematic review of literature was also performed. Results: By one year, 25 per cent of patients required adenoidectomy; the remaining children had no significant change in clinical score (p = 0.464), obstruction severity (p = 0.191) or allergic symptoms (p = 0.284). Fourteen pertinent studies were identified; all but one study showed improvement in the patients' symptoms and/or degree of obstruction. Two studies with follow up reaching 25 months showed positive effects. Conclusion: The short-term positive effect of some intranasal steroids on obstructive adenoids seems to persist in a significant number of patients after the cessation of treatment. Copyright © JLO (1984) Limited 2016.
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Adenoid, Follow-up studies, Intranasal drug administration, Mometasone furoate, Nasal obstruction, Steroids, Adenoidectomy, Adenoids, Administration, intranasal, Administration, topical, Anti-inflammatory agents, Child, Child, preschool, Female, Humans, Male, Prospective studies, Rhinitis, allergic, Severity of illness index, Time, Beclometasone, Flunisolide, Steroid, Antiinflammatory agent, Airway obstruction, Allergic rhinitis, Article, Bibliographic database, Cohort analysis, Disease severity, Drug effect, Follow up, Human, Long term care, Nasal pruritus, Nose obstruction, Obstructive adenoid, Outcome assessment, Pilot study, Prospective study, Short course therapy, Topical treatment, Treatment duration, Drug effects, Preschool child, Topical drug administration