Pain control in neonatal male circumcision: A best evidence review

Abstract

Objective: Routine male infant circumcision (RMIC) is a common procedure that inadvertently causes significant but preventable pain. In this best evidence review, we examine the available pain management options and their effectiveness for RMIC. Material and methods: The Medline (OVID) and Cochrane library were searched for randomized controlled trials investigating pain control for RMIC. Only trials that included newborns younger than 45 days of age were included. The articles generated in the initial search were screened independently by two of the authors. A third reviewer settled any discrepancies about the inclusion. Then, trials were categorized based on the type of intervention: topical anesthetics, oral sucrose, oral acetaminophen, nerve blocks, caudal blocks, circumcision device, non-pharmacological adjuncts, and multiple combinations. Results: Twenty-nine randomized clinical trials (RCTs) were found to address pain preventative measures in RMIC. As single agent, nerve blocks outperformed topical anesthetics and oral sucrose, as the latter two proved to be insufficient for proper pain control. Additionally, dorsal penile nerve block and ring blocks have a reasonable safety profile. The use of caudal blocks in RMIC was uncommon. Oral sucrose in association with swaddling or music are helpful and can be easily combined with other methods of pain management. Moreover, oral acetaminophen given perioperatively helps the patient recover. Ultimately, pain control should rely on a combination of anesthetics, analgesics, and kinesthetic methods to be administered before, during, and after the procedure for optimal outcome. Conclusion: RMIC is a painful procedure in need of proper pain control. Different interventions and agents have various abilities in controlling pain; however, developing a protocol centered around multimodal pain control proves to be the most effective. © 2020 Journal of Pediatric Urology Company