Impact of Adding Antithymocyte Globulin to Posttransplantation Cyclophosphamide in Haploidentical Stem-Cell Transplantation

Abstract

Background: Graft-versus-host disease (GVHD) is a major cause of mortality after allogeneic stem-cell transplantation. Posttransplantation cyclophosphamide (PT/CY) has become standard prophylaxis of GVHD in T-replete haploidentical transplantation. The question is whether adding antithymocyte globulin (ATG) to PT/CY may further reduce the incidence of GVHD compared to PT/CY only. Patients and Methods: We retrospectively studied 268 patients undergoing myeloablative haploidentical transplantation with thiotepa, busulfan, and fludarabine (TBF) conditioning. Sixty-nine patients (26%) received ATG. Results: In the ATG group, 3% died due to GVHD versus 8% in the no ATG group. The 100-day and 1-year nonrelapse mortality (NRM) was 0% and 19%, respectively, in the whole cohort. On univariate analysis, the 1-year NRM was 8% versus 23% in patients receiving ATG and no ATG, respectively (P =.005). The no ATG group had a higher incidence of acute GVHD at 12 months compared to the ATG group (22% vs. 12%, respectively, P =.029). The ATG group had better overall survival at 12 months compared to the no ATG group (79% vs. 69%, P =.029). On multivariate analysis, adding ATG to PT/CY had no significant impact on any of the outcomes. A low disease risk index was associated with better overall survival and lower NRM, while Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) score ≥ 3 was associated with higher NRM. Conclusion: ATG can be safely used as part of the pretransplantation conditioning and does not increase the incidence of relapse or complications after transplantation. © 2020 Elsevier Inc.; We conducted a retrospective analysis of 268 patients undergoing myeloablative haploidentical transplantation with thiotepa, busulfan, and fludarabine conditioning in order to evaluate the impact of adding antithymocyte globulin (ATG) to posttransplantation cyclophosphamide (PT/CY) on the incidence of graft-versus-host disease and transplantation outcomes. Sixty-nine patients (26%) received ATG while 199 patients (74%) did not receive ATG. ATG can be safely used as part of pretransplantation conditioning. © 2020 Elsevier Inc.