Preparation of 3-Substituted Isoindolin-1-one, Cinnoline, and 1,2,4-[ e]-Benzotriazine Derivatives

Simple item page
dc.contributor.authorEl Dhaibi, Fatat B.
dc.contributor.authorYoussef, Ali
dc.contributor.authorFettinger, James C.
dc.contributor.authorKurth, Mark J.
dc.contributor.authorHaddadin, Makhluf J.
dc.contributor.departmentDepartment of Chemistry
dc.contributor.facultyFaculty of Arts and Sciences (FAS)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:22:22Z
dc.date.available2025-01-24T11:22:22Z
dc.date.issued2022
dc.description.abstractHerein, we report a new approach to synthesize a series of 1,2,4-[e]-benzotriazine and cinnoline derivatives from 3-substituted isoindolin-1-one. All the reported products are obtained through an economical two-step synthetic procedure resulting in fair-to-high yields. Cinnolines (a) and 1,2,4-[e]-benzotriazines (b) result from an intramolecular cyclization of the corresponding 3-substituted isoindolin-1-ones, which, in turn, are prepared by an addition reaction from 2-cyanobenzaldehyde and 2-(2-nitrophenyl) acetonitrile (a) or 2-nitroaniline derivatives (b). A proposed mechanism for this transformation is presented. © 2022 American Chemical Society. All rights reserved.
dc.identifier.doihttps://doi.org/10.1021/acsomega.2c03045
dc.identifier.eid2-s2.0-85135874075
dc.identifier.urihttp://hdl.handle.net/10938/25495
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofACS Omega
dc.sourceScopus
dc.subjectChemistry (all)
dc.subjectChemical engineering (all)
dc.titlePreparation of 3-Substituted Isoindolin-1-one, Cinnoline, and 1,2,4-[ e]-Benzotriazine Derivatives
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2022-1598.pdf
Size:
2.13 MB
Format:
Adobe Portable Document Format
Download

Collections

Department of Chemistry