Therapeutic interventions in adult low-grade gliomas
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Korean Neurological Association
Abstract
Treating adult low-grade gliomas (LGGs) is particularly challenging due to the highly infil-trative nature of this type of brain cancer. Although surgery, radiotherapy, and chemotherapy are the mainstay treatment modalities for LGGs, the optimal combination management plan for a particular patient based on individual symptoms and the risk of treatment-induced toxicity remains unclear. This review highlights the competency and limitations of standard treatment options while providing an essential therapeutic update regarding current clinical trials aimed at implementing targeted therapies with morbidity rates lower than those for current LGG treatments and also augmenting the killing of cancerous cells while maintaining an improved quality of life. © 2019 Korean Neurological Association.
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Keywords
Brain cancer, Chemotherapy, Clinical trials, Low-grade glioma, Radiotherapy, Targeted therapy, 2 hydroxyglutaric acid, 6 o alkylguanine dna alkyltransferase, 6 o benzylguanine, Cancer antibody, Isocitrate dehydrogenase 1, Lomeguatrib, Lomustine, Methylated dna protein cysteine methyltransferase, Procarbazine, Protein p53, Temozolomide, Vincristine, Adult, Cancer adjuvant therapy, Cancer chemotherapy, Cancer grading, Cancer surgery, Clinical trial (topic), Constipation, Fatigue, Gene mutation, Glioblastoma, Glioma, High risk patient, Human, Leukoencephalopathy, Leukopenia, Low grade glioma, Lymphocytopenia, Mental health, Mini mental state examination, Molecularly targeted therapy, Morbidity, Nausea, Nuclear magnetic resonance imaging, Overall survival, Phase 2 clinical trial (topic), Phase 3 clinical trial (topic), Progression free survival, Quality of life, Radiation dose, Review, Tumor suppressor gene, Tumor volume, Whole brain radiotherapy