Therapeutic interventions in adult low-grade gliomas

Simple item page
dc.contributor.authorChammas, Majid
dc.contributor.authorSaadeh, Fadi S.
dc.contributor.authorMaaliki, Maya
dc.contributor.authorAssi, Hazem I.
dc.contributor.departmentInternal Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:54:26Z
dc.date.available2025-01-24T11:54:26Z
dc.date.issued2019
dc.description.abstractTreating adult low-grade gliomas (LGGs) is particularly challenging due to the highly infil-trative nature of this type of brain cancer. Although surgery, radiotherapy, and chemotherapy are the mainstay treatment modalities for LGGs, the optimal combination management plan for a particular patient based on individual symptoms and the risk of treatment-induced toxicity remains unclear. This review highlights the competency and limitations of standard treatment options while providing an essential therapeutic update regarding current clinical trials aimed at implementing targeted therapies with morbidity rates lower than those for current LGG treatments and also augmenting the killing of cancerous cells while maintaining an improved quality of life. © 2019 Korean Neurological Association.
dc.identifier.doihttps://doi.org/10.3988/jcn.2019.15.1.1
dc.identifier.eid2-s2.0-85059656045
dc.identifier.urihttp://hdl.handle.net/10938/31157
dc.language.isoen
dc.publisherKorean Neurological Association
dc.relation.ispartofJournal of Clinical Neurology (Korea)
dc.sourceScopus
dc.subjectBrain cancer
dc.subjectChemotherapy
dc.subjectClinical trials
dc.subjectLow-grade glioma
dc.subjectRadiotherapy
dc.subjectTargeted therapy
dc.subject2 hydroxyglutaric acid
dc.subject6 o alkylguanine dna alkyltransferase
dc.subject6 o benzylguanine
dc.subjectCancer antibody
dc.subjectIsocitrate dehydrogenase 1
dc.subjectLomeguatrib
dc.subjectLomustine
dc.subjectMethylated dna protein cysteine methyltransferase
dc.subjectProcarbazine
dc.subjectProtein p53
dc.subjectTemozolomide
dc.subjectVincristine
dc.subjectAdult
dc.subjectCancer adjuvant therapy
dc.subjectCancer chemotherapy
dc.subjectCancer grading
dc.subjectCancer surgery
dc.subjectClinical trial (topic)
dc.subjectConstipation
dc.subjectFatigue
dc.subjectGene mutation
dc.subjectGlioblastoma
dc.subjectGlioma
dc.subjectHigh risk patient
dc.subjectHuman
dc.subjectLeukoencephalopathy
dc.subjectLeukopenia
dc.subjectLow grade glioma
dc.subjectLymphocytopenia
dc.subjectMental health
dc.subjectMini mental state examination
dc.subjectMolecularly targeted therapy
dc.subjectMorbidity
dc.subjectNausea
dc.subjectNuclear magnetic resonance imaging
dc.subjectOverall survival
dc.subjectPhase 2 clinical trial (topic)
dc.subjectPhase 3 clinical trial (topic)
dc.subjectProgression free survival
dc.subjectQuality of life
dc.subjectRadiation dose
dc.subjectReview
dc.subjectTumor suppressor gene
dc.subjectTumor volume
dc.subjectWhole brain radiotherapy
dc.titleTherapeutic interventions in adult low-grade gliomas
dc.typeReview

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2019-7848.pdf
Size:
775.51 KB
Format:
Adobe Portable Document Format
Download

Collections

Internal Medicine