A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology
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MDPI
Abstract
Clonal hematopoiesis of indeterminate potential can be defined as genetic mutations that correlate in hematologic neoplasia such as myelodysplastic syndrome. Patients with cytopenia increasingly undergo molecular genetic tests of peripheral blood or bone marrow for diagnostic purposes. Recently, a new entity has been demarcated to lessen the risk of incorrect diagnoses of hematologic malignancies. This new entity is a potential precursor of myeloid diseases, analogous to monoclonal gammopathy of undetermined significance as a potential precursor of multiple myeloma. © 2022 by the authors.
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Chimeric antigen receptor t-cell therapy, Clonal hematopoeisis, Hematology, Mutations, Myeloma, Daratumumab, Isatuximab, Lenalidomide, Melphalan, Sirolimus, Thalidomide, Cancer growth, Cancer prognosis, Chemoradiotherapy, Chimeric antigen receptor t-cell immunotherapy, Clonal hematopoiesis of indeterminate potential, Cytogenetics, Cytopenia, Dna repair, Gene frequency, Gene mutation, Genetic analysis, Hematologic malignancy, High throughput sequencing, Human, Infection, Inflammation, Karyotyping, Monoclonal immunoglobulinemia, Multiple myeloma, Myelodysplastic syndrome, Overall survival, Progression free survival, Review, Somatic mutation, Whole exome sequencing