A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology

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dc.contributor.authorZerdan, Maroun Bou
dc.contributor.authorNasr, Lewis F.
dc.contributor.authorSaba, Ludovic
dc.contributor.authorMeouchy, Paul
dc.contributor.authorSafi, Nadine
dc.contributor.authorAllam, Sabine
dc.contributor.authorBhandari, Jenish
dc.contributor.authorChaulagain, Chakra P.
dc.contributor.departmentInternal Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:43:47Z
dc.date.available2025-01-24T11:43:47Z
dc.date.issued2022
dc.description.abstractClonal hematopoiesis of indeterminate potential can be defined as genetic mutations that correlate in hematologic neoplasia such as myelodysplastic syndrome. Patients with cytopenia increasingly undergo molecular genetic tests of peripheral blood or bone marrow for diagnostic purposes. Recently, a new entity has been demarcated to lessen the risk of incorrect diagnoses of hematologic malignancies. This new entity is a potential precursor of myeloid diseases, analogous to monoclonal gammopathy of undetermined significance as a potential precursor of multiple myeloma. © 2022 by the authors.
dc.identifier.doihttps://doi.org/10.3390/cancers14153663
dc.identifier.eid2-s2.0-85136632341
dc.identifier.urihttp://hdl.handle.net/10938/30352
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofCancers
dc.sourceScopus
dc.subjectChimeric antigen receptor t-cell therapy
dc.subjectClonal hematopoeisis
dc.subjectHematology
dc.subjectMutations
dc.subjectMyeloma
dc.subjectDaratumumab
dc.subjectIsatuximab
dc.subjectLenalidomide
dc.subjectMelphalan
dc.subjectSirolimus
dc.subjectThalidomide
dc.subjectCancer growth
dc.subjectCancer prognosis
dc.subjectChemoradiotherapy
dc.subjectChimeric antigen receptor t-cell immunotherapy
dc.subjectClonal hematopoiesis of indeterminate potential
dc.subjectCytogenetics
dc.subjectCytopenia
dc.subjectDna repair
dc.subjectGene frequency
dc.subjectGene mutation
dc.subjectGenetic analysis
dc.subjectHematologic malignancy
dc.subjectHigh throughput sequencing
dc.subjectHuman
dc.subjectInfection
dc.subjectInflammation
dc.subjectKaryotyping
dc.subjectMonoclonal immunoglobulinemia
dc.subjectMultiple myeloma
dc.subjectMyelodysplastic syndrome
dc.subjectOverall survival
dc.subjectProgression free survival
dc.subjectReview
dc.subjectSomatic mutation
dc.subjectWhole exome sequencing
dc.titleA Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology
dc.typeReview

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