Colorectal carcinogenesis: Role of oxidative stress and antioxidants
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International Institute of Anticancer Research
Abstract
One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.
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Keywords
Antioxidants, Colorectal cancer, Dysbiosis, Oxidative stress, Review, Animals, Carcinogenesis, Colorectal neoplasms, Humans, Reactive oxygen species, Alpha tocopherol, Anthocyanin, Antioxidant, Ascorbic acid, Beta carotene, Carotenoid, Catechin, Curcumin, Delta tocopherol, Epigallocatechin gallate, Fluorouracil, Gamma tocopherol, Hydrogen peroxide, Hydroxyl radical, Lycopene, Peroxynitrite, Polyphenol derivative, Quercetin, Reactive oxygen metabolite, Resveratrol, Retinol, Superoxide, Tocopherol derivative, Xanthophyll, Zeaxanthin, Antiinflammatory activity, Antineoplastic activity, Antioxidant activity, Antiproliferative activity, Cancer stem cell, Cell invasion, Cell population, Cell proliferation, Colon carcinogenesis, Colorectal cancer cell line, Colorectal carcinoma, Curcuma longa, Dna repair, Drug mechanism, Human, Human cell culture, In vitro study, In vivo study, Nonhuman, Priority journal, Tea, Animal, Colorectal tumor, Drug effects, Metabolism, Pathology